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DRUG:

thalidomide

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Company:

Generic mfg.

Drug class:

TNF inhibitor

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No biomarker	Multiple Myeloma	No biomarker	Multiple Myeloma	thalidomide Sensitive: A1 - Approval thalidomide Sensitive : A1	thalidomide Sensitive: A1 - Approval thalidomide Sensitive : A1
No biomarker	Multiple Myeloma	No biomarker	Multiple Myeloma	thalidomide + melphalan Sensitive: A1 - Approval thalidomide + melphalan Sensitive : A1	thalidomide + melphalan Sensitive: A1 - Approval thalidomide + melphalan Sensitive : A1
No biomarker	Multiple Myeloma	No biomarker	Multiple Myeloma	daratumumab + thalidomide Sensitive: A1 - Approval daratumumab + thalidomide Sensitive : A1	daratumumab + thalidomide Sensitive: A1 - Approval daratumumab + thalidomide Sensitive : A1
No biomarker	Multiple Myeloma	No biomarker	Multiple Myeloma	thalidomide + daratumumab/hyaluronidase Sensitive: A1 - Approval thalidomide + daratumumab / hyaluronidase Sensitive : A1	thalidomide + daratumumab/hyaluronidase Sensitive: A1 - Approval thalidomide + daratumumab / hyaluronidase Sensitive : A1
No biomarker	Kaposi Sarcoma	No biomarker	Kaposi Sarcoma	thalidomide Sensitive: A2 - Guideline thalidomide Sensitive : A2	thalidomide Sensitive: A2 - Guideline thalidomide Sensitive : A2
CRBN overexpression	Multiple Myeloma	CRBN overexpression	Multiple Myeloma	thalidomide Resistant: C3 – Early Trials thalidomide Resistant : C3	thalidomide Resistant: C3 – Early Trials thalidomide Resistant : C3
DDB1 overexpression	Multiple Myeloma	DDB1 overexpression	Multiple Myeloma	thalidomide Sensitive: C3 – Early Trials thalidomide Sensitive : C3	thalidomide Sensitive: C3 – Early Trials thalidomide Sensitive : C3
CUL4A overexpression	Multiple Myeloma	CUL4A overexpression	Multiple Myeloma	thalidomide Sensitive: C3 – Early Trials thalidomide Sensitive : C3	thalidomide Sensitive: C3 – Early Trials thalidomide Sensitive : C3
Chr del(17p)	Multiple Myeloma	Chr del(17p)	Multiple Myeloma	thalidomide Resistant: C3 – Early Trials thalidomide Resistant : C3	thalidomide Resistant: C3 – Early Trials thalidomide Resistant : C3
Chr amplification(1)(q21)	Multiple Myeloma	Chr amplification(1)(q21)	Multiple Myeloma	thalidomide Resistant: C3 – Early Trials thalidomide Resistant : C3	thalidomide Resistant: C3 – Early Trials thalidomide Resistant : C3
CRBN expression	Multiple Myeloma	CRBN expression	Multiple Myeloma	thalidomide Sensitive: C3 – Early Trials thalidomide Sensitive : C3	thalidomide Sensitive: C3 – Early Trials thalidomide Sensitive : C3
CUL4A expression	Multiple Myeloma	CUL4A expression	Multiple Myeloma	thalidomide Sensitive: C3 – Early Trials thalidomide Sensitive : C3	thalidomide Sensitive: C3 – Early Trials thalidomide Sensitive : C3
CRBN R283K	Multiple Myeloma	CRBN R283K	Multiple Myeloma	thalidomide Resistant: C4 – Case Studies thalidomide Resistant : C4	thalidomide Resistant: C4 – Case Studies thalidomide Resistant : C4
CRBN Q99	Multiple Myeloma	CRBN Q99	Multiple Myeloma	thalidomide Resistant: C4 – Case Studies thalidomide Resistant : C4	thalidomide Resistant: C4 – Case Studies thalidomide Resistant : C4
Chr t(11;14)(q13;q32)	Multiple Myeloma	Chr t(11;14)(q13;q32)	Multiple Myeloma	thalidomide Resistant: C4 – Case Studies thalidomide Resistant : C4	thalidomide Resistant: C4 – Case Studies thalidomide Resistant : C4