^
Association details:
Biomarker:CUL4A overexpression
Cancer:Multiple Myeloma
Drug:thalidomide (TNF inhibitor)
Direction:Sensitive
Evidence:
Evidence Level:
Sensitive: C3 – Early Trials
Source:
Title:

EXPRESSION SIGNIFICANCE OF CRL4-CRBN PROTEINS COMPLEX IN MULTIPLE MYELOMA PATIENTS TREATED WITH IMMUNOMODULATORY DRUGS.

Published date:
05/14/2020
Excerpt:
...the high CUL4A expression was associated with better response to IMiDs treatment (p=0.013) and longer PFS in comparison to the group of patient with low CUL4A level (p=0.027).