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    DRUG:

    thalidomide

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    Company:
    Generic mfg.
    Drug class:
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    Comparing the Addition of an Anti-Cancer Drug, Pomalidomide, to the Usual Chemotherapy Treatment (Daunorubicin and Cytarabine Liposome) in Newly Diagnosed Acute Myeloid Leukemia With Myelodysplastic Syndrome-Related Changes (NCT04802161)
    Phase 2
    National Cancer Institute (NCI)
    Active, not recruiting
    Last update posted :
    02/07/2025
    Initiation :
    08/24/2022
    Primary completion :
    12/31/2025
    Completion :
    12/31/2025
    RUNX1 • SF3B1 • ASXL1 • SRSF2 • BCOR • U2AF1 • STAG2 • ZRSR2
    |
    Chr del(11q)
    |
    Vyxeos (cytarabine/daunorubicin liposomal formulation) • pomalidomide • thalidomide
    UARK 2013-13, Total Therapy 4B - Formerly 2008-01 - A Phase III Trial for Low Risk Myeloma (TT4B) (NCT00734877)
    Phase 3
    University of Arkansas
    Active, not recruiting
    Last update posted :
    07/03/2024
    Initiation :
    07/01/2008
    Primary completion :
    09/01/2025
    Completion :
    09/01/2026
    TP53
    |
    TP53 deletion
    |
    cisplatin • bortezomib • doxorubicin hydrochloride • cyclophosphamide • etoposide IV • dexamethasone • thalidomide • melphalan
    Thalidomide Combined With Chemotherapy in the Treatment of Relapsed or Refractory Yolk Sac Tumor (NCT06470464)
    Phase 2
    Shandong First Medical University
    Completed
    Last update posted :
    06/24/2024
    Initiation :
    11/11/2021
    Primary completion :
    06/16/2024
    Completion :
    06/16/2024
    AFP
    |
    gemcitabine • albumin-bound paclitaxel • epirubicin • thalidomide
    Thalidomide Enhances Clinical Efficacy of Cetuximab Combined With Standard Chemotherapy for Left Colorectal Cancer (NCT06279351)
    Phase 2
    Xinqiao Hospital of Chongqing
    Not yet recruiting
    Last update posted :
    02/28/2024
    Initiation :
    04/01/2024
    Primary completion :
    12/31/2024
    Completion :
    12/31/2024
    BRAF
    |
    Erbitux (cetuximab) • 5-fluorouracil • irinotecan • thalidomide • leucovorin calcium
    The Maintenance Treatment of "ITIVA" in AML Patients (NCT06256627)
    Phase N/A
    Henan Cancer Hospital
    Recruiting
    Last update posted :
    02/13/2024
    Initiation :
    07/11/2023
    Primary completion :
    03/01/2025
    Completion :
    05/01/2027
    IL2
    |
    azacitidine • thalidomide
    Anti-Angiogenic Therapy Post Transplant (ASCR) for Pediatric Solid Tumors (NCT01661400)
    Phase 1
    Washington University School of Medicine
    Completed
    Last update posted :
    01/31/2024
    Initiation :
    10/26/2012
    Primary completion :
    12/27/2023
    Completion :
    12/27/2023
    CD34
    |
    cyclophosphamide • thalidomide • cyclophosphamide intravenous
    Daratumumab-bortezomib-dexamethasone (Dara-VCd) vs Bortezomib-Thalidomide-Dexamethasone (VTd), Then Maintenance With Ixazomib (IXA) or IXA-Dara (NCT03896737)
    Phase 2
    European Myeloma Network
    Active, not recruiting
    Last update posted :
    09/07/2023
    Initiation :
    04/16/2019
    Primary completion :
    05/01/2024
    Completion :
    02/01/2025
    IGH
    |
    IGH translocation
    |
    bortezomib • cyclophosphamide • Ninlaro (ixazomib) • Darzalex (daratumumab) • thalidomide • melphalan • cyclophosphamide intravenous
    UARK 2008-02 A Trial for High-risk Myeloma Evaluating Accelerating and Sustaining Complete Remission (NCT00869232)
    Phase 2
    University of Arkansas
    Active, not recruiting
    Last update posted :
    08/09/2023
    Initiation :
    10/01/2008
    Primary completion :
    10/01/2024
    Completion :
    10/01/2024
    SDC1
    |
    cisplatin • bortezomib • doxorubicin hydrochloride • cyclophosphamide • etoposide IV • thalidomide • melphalan • cyclophosphamide intravenous
    Escalating Doses of Thalidomide in Conjunction With Bortezomib and HIgh Dose Melphalan for BSCT (NCT01242267)
    Phase 1/2
    Hackensack Meridian Health
    Completed
    Last update posted :
    01/02/2023
    Initiation :
    05/11/2010
    Primary completion :
    01/20/2016
    Completion :
    01/20/2016
    BCL2 • CD34
    |
    bortezomib • thalidomide • melphalan • dexamethasone injection
    Alternating Thalidomide and Lenalidomide Therapy Plus Rituximab (ThRiL) as Initial Treatment for Patients With CLL (THRiL) (NCT01125176)
    Phase 2
    Weill Medical College of Cornell University
    Completed
    Last update posted :
    01/21/2022
    Initiation :
    03/30/2012
    Primary completion :
    12/20/2018
    Completion :
    12/29/2020
    CD20 • CD5 • FCER2
    |
    Rituxan (rituximab) • lenalidomide • thalidomide
    Thalidomide Combined With Chemotherapy and Monotherapy for Maintenance Treatment for Her2-negative Advanced GC (NCT05198856)
    Phase 1/2
    Qilu Hospital of Shandong University
    Not yet recruiting
    Last update posted :
    01/20/2022
    Initiation :
    03/10/2022
    Primary completion :
    03/10/2024
    Completion :
    12/10/2024
    HER-2
    |
    HER-2 negative
    |
    oxaliplatin • thalidomide
    Stem Cell Transplantation in Individuals With Multiple Myeloma (BMT CTN 0102) (NCT00075829)
    Phase 3
    National Heart, Lung, and Blood Institute (NHLBI)
    Completed
    Last update posted :
    11/01/2021
    Initiation :
    12/01/2003
    Primary completion :
    06/01/2012
    Completion :
    03/01/2013
    CD34
    |
    thalidomide
    Pyrotinib Plus Thalidomide in Advanced NSCLC Patients Harboring HER2 Exon 20 Insertions (NCT04382300)
    Phase 2
    Shanghai Chest Hospital
    Recruiting
    Last update posted :
    01/28/2021
    Initiation :
    06/30/2020
    Primary completion :
    10/01/2022
    Completion :
    04/01/2023
    HER-2
    |
    HER-2 exon 20 insertion • HER-2 exon 20 mutation • HER-2 exon 23 mutation
    |
    Irene (pyrotinib) • thalidomide
    Oblimersen, Thalidomide, and Dexamethasone in Treating Patients With Relapsed or Refractory Multiple Myeloma (NCT00049374)
    Phase 2
    University of Maryland, Baltimore
    Completed
    Last update posted :
    10/17/2019
    Initiation :
    09/01/2002
    Primary completion :
    01/01/2006
    Completion :
    01/01/2006
    BCL2
    |
    dexamethasone • thalidomide • Genasense (oblimersen)
    Tamoxifen Compared With Thalidomide in Treating Women With Ovarian Epithelial Cancer, Fallopian Tube Cancer, or Primary Peritoneal Cancer (NCT00041080)
    Phase 3
    National Cancer Institute (NCI)
    Completed
    Last update posted :
    07/30/2019
    Initiation :
    02/01/2003
    Primary completion :
    01/01/2011
    Completion :
    01/01/2011
    MUC16
    |
    tamoxifen • thalidomide • Soltamox (tamoxifen citrate)
    Study of Thalidomide in Treatment of Advanced Nsclc (Dream-003) (NCT03062800)
    Phase 2
    Qilu Hospital of Shandong University
    Unknown status
    Last update posted :
    06/05/2019
    Initiation :
    12/01/2016
    Primary completion :
    12/01/2020
    Completion :
    11/01/2021
    EGFR • VEGFA
    |
    EGFR mutation
    |
    cisplatin • carboplatin • pemetrexed • thalidomide
    The Evaluation of Curative Effect on Treatment of Tumor Above Thalidomide Combined With Megestrol (NCT03777930)
    Phase 4
    Shenzhen Fifth People's Hospital
    Unknown status
    Last update posted :
    12/19/2018
    Initiation :
    12/10/2018
    Primary completion :
    10/10/2020
    Completion :
    06/10/2021
    IFNG • IL6 • TNFA • IL2 • IL10 • IL17A • IL21 • IL22
    |
    thalidomide • megestrol
    Study of Paclitaxel, Estramustine Phosphate and Thalidomide for Patients With Metastatic Androgen-Independent Prostate Carcinoma (NCT00038246)
    Phase 1/2
    M.D. Anderson Cancer Center
    Completed
    Last update posted :
    10/31/2018
    Initiation :
    10/01/2000
    Primary completion :
    02/01/2004
    Completion :
    12/01/2004
    EGFR
    |
    paclitaxel • thalidomide • Emcyt (estramustine)
    Phase II Study of RT-PEPC in Relapsed Mantle Cell Lymphoma (NCT00151281)
    Phase 2
    Weill Medical College of Cornell University
    Completed
    Last update posted :
    06/28/2018
    Initiation :
    11/01/2004
    Primary completion :
    12/01/2009
    Completion :
    04/07/2011
    CD20 • CCND1 • CD5 • MME • FCER2
    |
    Rituxan (rituximab) • cyclophosphamide • etoposide IV • prednisone • thalidomide • Matulane (procarbazine hydrochloride)
    EGFR Mutation Positive NSCLC Patients With Gefitinib and Thalidomide (CSWOG002) (NCT03341494)
    Phase 2
    Fujian Cancer Hospital
    Unknown status
    Last update posted :
    11/14/2017
    Initiation :
    04/01/2017
    Primary completion :
    11/01/2019
    Completion :
    11/01/2020
    EGFR
    |
    EGFR mutation • EGFR L858R • EGFR exon 19 deletion
    |
    gefitinib • thalidomide
    Thalidomide Combined With R-CHOP in Newly Diagnosed，Untreated Double-expressor Diffuse Large B-Cell Lymphoma Patients (NCT03318835)
    Phase 3
    Fudan University
    Unknown status
    Last update posted :
    10/24/2017
    Initiation :
    08/22/2017
    Primary completion :
    08/22/2020
    Completion :
    08/22/2020
    BCL2
    |
    Rituxan (rituximab) • doxorubicin hydrochloride • cyclophosphamide • thalidomide
    Chidamide With PET Regimen for Angioimmunoblastic T Cell Lymphoma (PET: Prednisone, Etoposide and Thalidomide) (NCT03273452)
    Phase 2
    Qingdao University
    Unknown status
    Last update posted :
    09/25/2017
    Initiation :
    03/01/2017
    Primary completion :
    02/01/2019
    Completion :
    05/01/2019
    CD20 • PD-1 • BCL6 • CD4 • CXCL13 • MME • CR1
    |
    etoposide IV • prednisone • Epidaza (chidamide) • thalidomide
    Studying Blood Samples From Patients With Multiple Myeloma Who Were Treated With Thalidomide or Lenalidomide (NCT00899080)
    Phase N/A
    Eastern Cooperative Oncology Group
    Completed
    Last update posted :
    05/17/2017
    Initiation :
    07/04/2008
    Primary completion :
    08/04/2008
    Completion :
    08/04/2008
    CTSG
    |
    lenalidomide • thalidomide
    Conmana Combined With Thalidomide to Treat NSCLC (NCT02778893)
    Phase 4
    Henan Provincial People's Hospital
    Unknown status
    Last update posted :
    05/20/2016
    Initiation :
    03/01/2016
    Primary completion :
    03/01/2017
    Completion :
    03/01/2020
    EGFR
    |
    EGFR mutation
    |
    Conmana (icotinib) • thalidomide