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Association details:
Biomarker:
DDB1 overexpression
Cancer:
Multiple Myeloma
Drug:
thalidomide
(
TNF inhibitor
)
Direction:
Sensitive
Evidence:
Evidence Level:
Sensitive: C3 – Early Trials
Source:
EHA 2020
Title:
EXPRESSION SIGNIFICANCE OF CRL4-CRBN PROTEINS COMPLEX IN MULTIPLE MYELOMA PATIENTS TREATED WITH IMMUNOMODULATORY DRUGS.
Published date:
05/14/2020
Excerpt:
The high DDB1 expression, as the only one, was associated with longer OS of MM patients treated with thalidomide or lenalidomide (p=0.002).
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