STAT3 inhibitor

DRUG CLASS:

STAT3 inhibitor

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No biomarker	Hepatocellular Cancer	No biomarker	Hepatocellular Cancer	TTI-101 oral Sensitive: B - Late Trials TTI-101 oral Sensitive : B	TTI-101 oral Sensitive: B - Late Trials TTI-101 oral Sensitive : B
MSI-H/dMMR	Prostate Cancer	MSI-H/dMMR	Prostate Cancer	pembrolizumab + BBI608 Sensitive: C3 – Early Trials pembrolizumab + BBI608 Sensitive : C3	pembrolizumab + BBI608 Sensitive: C3 – Early Trials pembrolizumab + BBI608 Sensitive : C3
EML4-ALK G1202R	Non Small Cell Lung Cancer	EML4-ALK G1202R	Non Small Cell Lung Cancer	ALK inhibitor + STAT3 inhibitor Sensitive: C3 – Early Trials ALK inhibitor + STAT3 inhibitor Sensitive : C3	ALK inhibitor + STAT3 inhibitor Sensitive: C3 – Early Trials ALK inhibitor + STAT3 inhibitor Sensitive : C3
BCR-ABL1 T315I	Chronic Myeloid Leukemia	BCR-ABL1 T315I	Chronic Myeloid Leukemia	NT-157 Sensitive: D – Preclinical NT-157 Sensitive : D	NT-157 Sensitive: D – Preclinical NT-157 Sensitive : D
MUC1 overexpression	Pancreatic Ductal Adenocarcinoma	MUC1 overexpression	Pancreatic Ductal Adenocarcinoma	BBI608 Sensitive: D – Preclinical BBI608 Sensitive : D	BBI608 Sensitive: D – Preclinical BBI608 Sensitive : D
STAT3 expression	Gastric Cancer	STAT3 expression	Gastric Cancer	BBI608 Sensitive: D – Preclinical BBI608 Sensitive : D	BBI608 Sensitive: D – Preclinical BBI608 Sensitive : D
NFKB1 expression	Gastric Cancer	NFKB1 expression	Gastric Cancer	BBI608 Sensitive: D – Preclinical BBI608 Sensitive : D	BBI608 Sensitive: D – Preclinical BBI608 Sensitive : D
FLT3 mutation	Acute Myelogenous Leukemia	FLT3 mutation	Acute Myelogenous Leukemia	ASP7487 + NT-157 Sensitive: D – Preclinical ASP7487 + NT-157 Sensitive : D	ASP7487 + NT-157 Sensitive: D – Preclinical ASP7487 + NT-157 Sensitive : D
PTPRD mutation	Squamous Cell Carcinoma of Head and Neck	PTPRD mutation	Squamous Cell Carcinoma of Head and Neck	JSI-124 Sensitive: D – Preclinical JSI-124 Sensitive : D	JSI-124 Sensitive: D – Preclinical JSI-124 Sensitive : D
PTPRT promoter methylation	Squamous Cell Carcinoma of Head and Neck	PTPRT promoter methylation	Squamous Cell Carcinoma of Head and Neck	JSI-124 Sensitive: D – Preclinical JSI-124 Sensitive : D	JSI-124 Sensitive: D – Preclinical JSI-124 Sensitive : D
PTPRT promoter methylation	Squamous Cell Carcinoma of Head and Neck	PTPRT promoter methylation	Squamous Cell Carcinoma of Head and Neck	stattic Sensitive: D – Preclinical stattic Sensitive : D	stattic Sensitive: D – Preclinical stattic Sensitive : D
STAT3 mutation	Uterine Cancer	STAT3 mutation	Uterine Cancer	STAT3 inhibitor Sensitive: D – Preclinical STAT3 inhibitor Sensitive : D	STAT3 inhibitor Sensitive: D – Preclinical STAT3 inhibitor Sensitive : D
STAT3 mutation	Ovarian Cancer	STAT3 mutation	Ovarian Cancer	STAT3 inhibitor Sensitive: D – Preclinical STAT3 inhibitor Sensitive : D	STAT3 inhibitor Sensitive: D – Preclinical STAT3 inhibitor Sensitive : D
HER-2 positive	HER2 Positive Breast Cancer	HER-2 positive	HER2 Positive Breast Cancer	niclosamide Sensitive: D – Preclinical niclosamide Sensitive : D	niclosamide Sensitive: D – Preclinical niclosamide Sensitive : D
ALK rearrangement	Lung Cancer	ALK rearrangement	Lung Cancer	alectinib + YHO-1701 Sensitive: D – Preclinical alectinib + YHO-1701 Sensitive : D	alectinib + YHO-1701 Sensitive: D – Preclinical alectinib + YHO-1701 Sensitive : D
KRAS G12C	Lung Adenocarcinoma	KRAS G12C	Lung Adenocarcinoma	TTI-101 oral Sensitive: D – Preclinical TTI-101 oral Sensitive : D	TTI-101 oral Sensitive: D – Preclinical TTI-101 oral Sensitive : D
STAT3 expression	Breast Cancer	STAT3 expression	Breast Cancer	BP1003 Sensitive: D – Preclinical BP1003 Sensitive : D	BP1003 Sensitive: D – Preclinical BP1003 Sensitive : D
STAT3 expression	Ovarian Cancer	STAT3 expression	Ovarian Cancer	BP1003 Sensitive: D – Preclinical BP1003 Sensitive : D	BP1003 Sensitive: D – Preclinical BP1003 Sensitive : D
FLT3-ITD mutation	Acute Myelogenous Leukemia	FLT3-ITD mutation	Acute Myelogenous Leukemia	EC-70124 Sensitive: D – Preclinical EC-70124 Sensitive : D	EC-70124 Sensitive: D – Preclinical EC-70124 Sensitive : D
BRAF mutation	Melanoma	BRAF mutation	Melanoma	PD1 inhibitor + STAT3 inhibitor Sensitive: D – Preclinical PD1 inhibitor + STAT3 inhibitor Sensitive : D	PD1 inhibitor + STAT3 inhibitor Sensitive: D – Preclinical PD1 inhibitor + STAT3 inhibitor Sensitive : D
MUC4 expression	HER2 Positive Breast Cancer	MUC4 expression	HER2 Positive Breast Cancer	fam-trastuzumab deruxtecan-nxki + INB03 Sensitive: D – Preclinical fam-trastuzumab deruxtecan-nxki + INB03 Sensitive : D	fam-trastuzumab deruxtecan-nxki + INB03 Sensitive: D – Preclinical fam-trastuzumab deruxtecan-nxki + INB03 Sensitive : D

STAT3 inhibitor

STAT3 inhibitor

Associations(21)

Associations
(21)