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Association details:
Biomarker:NFKB1 expression
Cancer:Gastric Cancer
Drug:napabucasin (BBI608) (STAT3 inhibitor)
Direction:Sensitive
Evidence:
Evidence Level:
Sensitive: D – Preclinical
Title:

Loss of Tff1 promotes H.pylori-mediated Stat3 activation through Nfkb pathway

Published date:
05/15/2020
Excerpt:
Using TFF1-KO mice, treatment with BAY or Napabucasin after PMSS1 infection was able to decrease the expression of NF-κB and STAT3 target genes as compared to non-treated infected mice….results suggest the anti-inflammatory and active role of TFF1 in suppressing gastric tumorigenesis.