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Association details:
| Biomarker: | STAT3 expression |
|---|---|
| Cancer: | Gastric Cancer |
| Drug: | napabucasin (BBI608) (STAT3 inhibitor) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
Loss of Tff1 promotes H.pylori-mediated Stat3 activation through Nfkb pathway
Published date:
05/15/2020
Excerpt:
Using TFF1-KO mice, treatment with BAY or Napabucasin after PMSS1 infection was able to decrease the expression of NF-κB and STAT3 target genes as compared to non treated infected mice….results suggest the anti-inflammatory and active role of TFF1 in suppressing gastric tumorigenesis.
