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    Association details:
    Biomarker:MUC1 overexpression
    Cancer:Pancreatic Ductal Adenocarcinoma
    Drug:napabucasin (BBI608) (STAT3 inhibitor)
    Direction:Sensitive
    Evidence:
    Evidence Level:
    Sensitive: D – Preclinical
    Source:
    AACR-II 2020
    Title:

    Abstract 1837: MUC1 confers sensitivity to STAT-3 inhibitor napabucasin in pancreatic ductal adenocarcinoma cells

    Published date:
    05/15/2020
    Excerpt:
    The cells with high MUC1, CFPAC and Capan 1 showed increased susceptibility to Napabucasin at lower doses (IC50 - 2.088uM and 0.371uM respectively) compared to cells with low MUC1…
    DOI:
    10.1158/1538-7445.AM2020-1837