PIK3R1 mutation	Hormone Receptor Positive Breast Cancer	PIK3R1 mutation	Hormone Receptor Positive Breast Cancer	lenvatinib Resistant: C3 – Early Trials lenvatinib Resistant : C3	lenvatinib Resistant: C3 – Early Trials lenvatinib Resistant : C3
PIK3R1 overexpression	Melanoma	PIK3R1 overexpression	Melanoma	PD1 inhibitor Sensitive: C3 – Early Trials PD1 inhibitor Sensitive : C3	PD1 inhibitor Sensitive: C3 – Early Trials PD1 inhibitor Sensitive : C3
PIK3R1 mutation	Endometrial Cancer	PIK3R1 mutation	Endometrial Cancer	LY3023414 Sensitive: C3 – Early Trials LY3023414 Sensitive : C3	LY3023414 Sensitive: C3 – Early Trials LY3023414 Sensitive : C3
PIK3R1 mutation + FGFR2 rearrangement	Cholangiocarcinoma	PIK3R1 mutation + FGFR2 rearrangement	Cholangiocarcinoma	futibatinib Sensitive: C3 – Early Trials futibatinib Sensitive : C3	futibatinib Sensitive: C3 – Early Trials futibatinib Sensitive : C3
PIK3R1 overexpression	Soft Tissue Sarcoma	PIK3R1 overexpression	Soft Tissue Sarcoma	olaparib Sensitive: C3 – Early Trials olaparib Sensitive : C3	olaparib Sensitive: C3 – Early Trials olaparib Sensitive : C3
PIK3R1 mutation + HER-2 positive	Gastric Cancer	PIK3R1 mutation + HER-2 positive	Gastric Cancer	trastuzumab Sensitive: C3 – Early Trials trastuzumab Sensitive : C3	trastuzumab Sensitive: C3 – Early Trials trastuzumab Sensitive : C3
PIK3R1 M326I	Gastric Cancer	PIK3R1 M326I	Gastric Cancer	GSK2636771 Sensitive: C3 – Early Trials GSK2636771 Sensitive : C3	GSK2636771 Sensitive: C3 – Early Trials GSK2636771 Sensitive : C3
PIK3R1 EY451delinsD	HER2 Positive Breast Cancer	PIK3R1 EY451delinsD	HER2 Positive Breast Cancer	trastuzumab + everolimus Sensitive: C4 – Case Studies trastuzumab + everolimus Sensitive : C4	trastuzumab + everolimus Sensitive: C4 – Case Studies trastuzumab + everolimus Sensitive : C4
TMB-L + ARID1A deletion + CDKN2A deletion + CDKN2B deletion + MTAP deletion + PIK3R1 N564D + NBN P81fs*23	Gallbladder Cancer	TMB-L + ARID1A deletion + CDKN2A deletion + CDKN2B deletion + MTAP deletion + PIK3R1 N564D + NBN P81fs*23	Gallbladder Cancer	BMS‐986504 Sensitive: C4 – Case Studies BMS‐986504 Sensitive : C4	BMS‐986504 Sensitive: C4 – Case Studies BMS‐986504 Sensitive : C4
PIK3R1 mutation	Breast Cancer	PIK3R1 mutation	Breast Cancer	alpelisib + L-NMMA Sensitive: D – Preclinical alpelisib + L-NMMA Sensitive : D	alpelisib + L-NMMA Sensitive: D – Preclinical alpelisib + L-NMMA Sensitive : D

PIK3R1 (Phosphoinositide-3-Kinase Regulatory Subunit 1)

Associations(10)

Associations
(10)