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DRUG:

pevonedistat (MLN4924)

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Company:

Takeda

Drug class:

NEDD8 activating enzyme inhibitor

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No biomarker	Myelodysplastic Syndrome	No biomarker	Myelodysplastic Syndrome	MLN4924 Sensitive: B - Late Trials MLN4924 Sensitive : B	MLN4924 Sensitive: B - Late Trials MLN4924 Sensitive : B
TP53 mutation	Acute Myelogenous Leukemia	TP53 mutation	Acute Myelogenous Leukemia	venetoclax + MLN4924 Sensitive: C3 – Early Trials venetoclax + MLN4924 Sensitive : C3	venetoclax + MLN4924 Sensitive: C3 – Early Trials venetoclax + MLN4924 Sensitive : C3
PTEN deletion	Glioblastoma	PTEN deletion	Glioblastoma	MLN4924 Resistant: C3 – Early Trials MLN4924 Resistant : C3	MLN4924 Resistant: C3 – Early Trials MLN4924 Resistant : C3
MECOM rearrangement	Acute Myelogenous Leukemia	MECOM rearrangement	Acute Myelogenous Leukemia	MLN4924 + ABBV-167 Sensitive: C3 – Early Trials MLN4924 + ABBV-167 Sensitive : C3	MLN4924 + ABBV-167 Sensitive: C3 – Early Trials MLN4924 + ABBV-167 Sensitive : C3
BRAF mutation + TET2 mutation	Acute Myelogenous Leukemia	BRAF mutation + TET2 mutation	Acute Myelogenous Leukemia	MLN4924 + belinostat Sensitive: C4 – Case Studies MLN4924 + belinostat Sensitive : C4	MLN4924 + belinostat Sensitive: C4 – Case Studies MLN4924 + belinostat Sensitive : C4
PTEN mutation	Glioblastoma	PTEN mutation	Glioblastoma	MLN4924 Resistant: D – Preclinical MLN4924 Resistant : D	MLN4924 Resistant: D – Preclinical MLN4924 Resistant : D
PTEN deletion	Glioma	PTEN deletion	Glioma	MLN4924 Resistant: D – Preclinical MLN4924 Resistant : D	MLN4924 Resistant: D – Preclinical MLN4924 Resistant : D
PTEN mutation	Glioma	PTEN mutation	Glioma	MLN4924 Resistant: D – Preclinical MLN4924 Resistant : D	MLN4924 Resistant: D – Preclinical MLN4924 Resistant : D
ER positive	Estrogen Receptor Positive Breast Cancer	ER positive	Estrogen Receptor Positive Breast Cancer	MLN4924 Sensitive: D – Preclinical MLN4924 Sensitive : D	MLN4924 Sensitive: D – Preclinical MLN4924 Sensitive : D
PTEN deletion	Breast Cancer	PTEN deletion	Breast Cancer	MLN4924 Resistant: D – Preclinical MLN4924 Resistant : D	MLN4924 Resistant: D – Preclinical MLN4924 Resistant : D
BRCA wild-type	Triple Negative Breast Cancer	BRCA wild-type	Triple Negative Breast Cancer	MLN4924 Sensitive: D – Preclinical MLN4924 Sensitive : D	MLN4924 Sensitive: D – Preclinical MLN4924 Sensitive : D