^
Association details:
| Biomarker: | PTEN mutation |
|---|---|
| Cancer: | Glioblastoma |
| Drug: | pevonedistat (MLN4924) (NEDD8 activating enzyme inhibitor) |
| Direction: | Resistant |
Evidence:
Source:
Title:
Loss of PTEN confers resistance to neddylation inhibition through TOP2A in glioblastoma
Excerpt:
...mutations and deletions in phosphatase and tensin homolog (PTEN) are associated with resistance to MLN4924 in both low-grade gliomas and GBM.
