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    Association details:
    Biomarker:PTEN mutation
    Cancer:Glioblastoma
    Drug:pevonedistat (MLN4924) (NEDD8 activating enzyme inhibitor)
    Direction:Resistant
    Evidence:
    Evidence Level:
    Resistant: D – Preclinical
    New
    Source:
    AACR-II 2020
    Title:

    Loss of PTEN confers resistance to neddylation inhibition through TOP2A in glioblastoma

    Excerpt:
    ...mutations and deletions in phosphatase and tensin homolog (PTEN) are associated with resistance to MLN4924 in both low-grade gliomas and GBM.