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Association details:
Evidence:
Evidence Level:
Resistant: C3 – Early Trials
Title:

PTEN loss drives resistance to the neddylation inhibitor MLN4924 in glioblastoma and can be overcome with TOP2A inhibitors

Published date:
03/19/2022
Excerpt:
We report vulnerability to MLN4924 or pevonedistat (a neddylation inhibitor) in a subset of glioblastoma (GBM) preclinical models and identify biomarkers, mechanisms, and signatures of differential response....Loss of PTEN and its nuclear functions is associated with resistance to MLN4924.
DOI:
10.1093/neuonc/noac067
Evidence Level:
Resistant: D – Preclinical
New
Title:

Loss of PTEN confers resistance to neddylation inhibition through TOP2A in glioblastoma

Excerpt:
...mutations and deletions in phosphatase and tensin homolog (PTEN) are associated with resistance to MLN4924 in both low-grade gliomas and GBM.