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Association details:
| Biomarker: | PTEN deletion |
|---|---|
| Cancer: | Breast Cancer |
| Drug: | pevonedistat (MLN4924) (NEDD8 activating enzyme inhibitor) |
| Direction: | Resistant |
Evidence:
Source:
Title:
The Absence of PTEN in Breast Cancer Is a Driver of MLN4924 Resistance
Published date:
04/30/2021
Excerpt:
Our data show that the anti-tumor efficacy of MLN4924 in breast cancer cells was markedly reduced with the deletion of PTEN...PTEN status thus may help to identify MLN4924-responsive breast cancer patients.
DOI:
10.3389/fcell.2021.667435
