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BIOMARKER:
NPM1-ALK fusion
i
Other names:
Nucleophosmin (Nucleolar Phosphoprotein B23, Numatrin), Testicular Tissue Protein Li 128, Nucleolar Protein NO38, Numatrin, NPM1, Nucleophosmin 1, Nucleophosmin/Nucleoplasmin Family, Member 1, Nucleolar Phosphoprotein B23, NBLST3, CD246, Anaplastic Lymphoma Kinase, Anaplastic Lymphoma Kinase (Ki-1), CD246 Antigen, Mutant Anaplastic Lymphoma Kinase, ALK, ALK Receptor Tyrosine Kinase, Anaplastic Lymphoma Receptor Tyrosine Kinase, ALK Tyrosine Kinase Receptor
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Entrez ID:
238
;
4869
Related biomarkers:
Expression
Mutation
CNA
Fusion
Others
‹
ALK positive (74)
ALK negative (4)
EGFR negative + ALK negative (4)
EGFR expression + ALK positive (3)
NPM1 expression (2)
ALK expression + PDGFRA expression (1)
ALK expression + PDGFRB expression (1)
ALK overexpression (1)
ALK positive + ROS1 positive (1)
ALK positive + YAP1 overexpression (1)
ALK positive + YES1 overexpression (1)
KRT7 positive + NKX2-1 positive + ALK overexpression (1)
CCDC86 expression + NPM1 expression (1)
ALK positive (74)
ALK negative (4)
EGFR negative + ALK negative (4)
EGFR expression + ALK positive (3)
NPM1 expression (2)
ALK expression + PDGFRA expression (1)
ALK expression + PDGFRB expression (1)
ALK overexpression (1)
ALK positive + ROS1 positive (1)
ALK positive + YAP1 overexpression (1)
ALK positive + YES1 overexpression (1)
KRT7 positive + NKX2-1 positive + ALK overexpression (1)
CCDC86 expression + NPM1 expression (1)
›
Associations
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NPM1-ALK fusion
T Cell Non-Hodgkin Lymphoma
NPM1-ALK fusion
T Cell Non-Hodgkin Lymphoma
ceritinib
Sensitive: C4 – Case Studies
ceritinib
Sensitive
:
C4
ceritinib
Sensitive: C4 – Case Studies
ceritinib
Sensitive
:
C4
NPM1-ALK fusion
T Cell Non-Hodgkin Lymphoma
NPM1-ALK fusion
T Cell Non-Hodgkin Lymphoma
gilteritinib
Sensitive: D – Preclinical
gilteritinib
Sensitive
:
D
gilteritinib
Sensitive: D – Preclinical
gilteritinib
Sensitive
:
D
NPM1-ALK fusion
Non-Hodgkin’s Lymphoma
NPM1-ALK fusion
Non-Hodgkin’s Lymphoma
crizotinib
Sensitive: D – Preclinical
crizotinib
Sensitive
:
D
crizotinib
Sensitive: D – Preclinical
crizotinib
Sensitive
:
D
NPM1-ALK fusion
Non-Hodgkin’s Lymphoma
NPM1-ALK fusion
Non-Hodgkin’s Lymphoma
gilteritinib
Sensitive: D – Preclinical
gilteritinib
Sensitive
:
D
gilteritinib
Sensitive: D – Preclinical
gilteritinib
Sensitive
:
D
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