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Association details:
Biomarker:
NPM1-ALK fusion
Cancer:
Non-Hodgkin’s Lymphoma
Drug:
Xospata (gilteritinib)
(
Multi-tyrosine kinase inhibitor
)
Direction:
Sensitive
Evidence:
Evidence Level:
Sensitive: D – Preclinical
Source:
Nat Commun
Title:
Gilteritinib overcomes lorlatinib resistance in ALK-rearranged cancer
Published date:
02/24/2021
Excerpt:
...gilteritinib exhibited efficacy against NPM-ALK fusion oncogene-positive KARPAS 299 cells, a non-Hodgkin’s Ki-positive large cell lymphoma cell line...
DOI:
10.1038/s41467-021-21396-w
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