CANCER:

Mucosal Melanoma

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Melanoma (1010)

Ocular Melanoma (105)

Uveal Melanoma (101)

Cutaneous Melanoma (87)

Melanoma (1010)

Ocular Melanoma (105)

Uveal Melanoma (101)

Cutaneous Melanoma (87)

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CDK4 amplification	Mucosal Melanoma	CDK4 amplification	Mucosal Melanoma	dalpiciclib Sensitive: C3 – Early Trials ESMO 2022 - 3 weeks (New C3) dalpiciclib Sensitive : C3 ESMO 2022 - 3wk	dalpiciclib Sensitive: C3 – Early Trials ESMO 2022 - 3 weeks dalpiciclib Sensitive : C3 ESMO 2022 - 3 weeks - (New C3)
No biomarker	Mucosal Melanoma	No biomarker	Mucosal Melanoma	toripalimab Sensitive: B - Late Trials toripalimab Sensitive : B	toripalimab Sensitive: B - Late Trials toripalimab Sensitive : B
No biomarker	Mucosal Melanoma	No biomarker	Mucosal Melanoma	ALKS 4230 Sensitive: B - Late Trials ALKS 4230 Sensitive : B	ALKS 4230 Sensitive: B - Late Trials ALKS 4230 Sensitive : B
BRAF mutation	Mucosal Melanoma	BRAF mutation	Mucosal Melanoma	PD1 inhibitor Sensitive: C3 – Early Trials PD1 inhibitor Sensitive : C3	PD1 inhibitor Sensitive: C3 – Early Trials PD1 inhibitor Sensitive : C3
KIT mutation	Mucosal Melanoma	KIT mutation	Mucosal Melanoma	PD1 inhibitor Sensitive: C3 – Early Trials PD1 inhibitor Sensitive : C3	PD1 inhibitor Sensitive: C3 – Early Trials PD1 inhibitor Sensitive : C3
MDM2 amplification	Mucosal Melanoma	MDM2 amplification	Mucosal Melanoma	ipilimumab Resistant: C3 – Early Trials ipilimumab Resistant : C3	ipilimumab Resistant: C3 – Early Trials ipilimumab Resistant : C3
MDM4 amplification	Mucosal Melanoma	MDM4 amplification	Mucosal Melanoma	ipilimumab Resistant: C3 – Early Trials ipilimumab Resistant : C3	ipilimumab Resistant: C3 – Early Trials ipilimumab Resistant : C3
MDM2 amplification	Mucosal Melanoma	MDM2 amplification	Mucosal Melanoma	nivolumab + ipilimumab Resistant: C3 – Early Trials nivolumab + ipilimumab Resistant : C3	nivolumab + ipilimumab Resistant: C3 – Early Trials nivolumab + ipilimumab Resistant : C3
MDM2 amplification	Mucosal Melanoma	MDM2 amplification	Mucosal Melanoma	nivolumab Resistant: C3 – Early Trials nivolumab Resistant : C3	nivolumab Resistant: C3 – Early Trials nivolumab Resistant : C3
MDM4 amplification	Mucosal Melanoma	MDM4 amplification	Mucosal Melanoma	nivolumab + ipilimumab Resistant: C3 – Early Trials nivolumab + ipilimumab Resistant : C3	nivolumab + ipilimumab Resistant: C3 – Early Trials nivolumab + ipilimumab Resistant : C3
MDM4 amplification	Mucosal Melanoma	MDM4 amplification	Mucosal Melanoma	nivolumab Resistant: C3 – Early Trials nivolumab Resistant : C3	nivolumab Resistant: C3 – Early Trials nivolumab Resistant : C3
EGFR amplification	Mucosal Melanoma	EGFR amplification	Mucosal Melanoma	ipilimumab Resistant: C3 – Early Trials ipilimumab Resistant : C3	ipilimumab Resistant: C3 – Early Trials ipilimumab Resistant : C3
EGFR amplification	Mucosal Melanoma	EGFR amplification	Mucosal Melanoma	nivolumab Resistant: C3 – Early Trials nivolumab Resistant : C3	nivolumab Resistant: C3 – Early Trials nivolumab Resistant : C3
EGFR amplification	Mucosal Melanoma	EGFR amplification	Mucosal Melanoma	nivolumab + ipilimumab Resistant: C3 – Early Trials nivolumab + ipilimumab Resistant : C3	nivolumab + ipilimumab Resistant: C3 – Early Trials nivolumab + ipilimumab Resistant : C3
EGFR amplification	Mucosal Melanoma	EGFR amplification	Mucosal Melanoma	pembrolizumab Resistant: C3 – Early Trials pembrolizumab Resistant : C3	pembrolizumab Resistant: C3 – Early Trials pembrolizumab Resistant : C3
MDM4 amplification	Mucosal Melanoma	MDM4 amplification	Mucosal Melanoma	pembrolizumab Resistant: C3 – Early Trials pembrolizumab Resistant : C3	pembrolizumab Resistant: C3 – Early Trials pembrolizumab Resistant : C3
MDM2 amplification	Mucosal Melanoma	MDM2 amplification	Mucosal Melanoma	pembrolizumab Resistant: C3 – Early Trials pembrolizumab Resistant : C3	pembrolizumab Resistant: C3 – Early Trials pembrolizumab Resistant : C3
NRAS mutation	Mucosal Melanoma	NRAS mutation	Mucosal Melanoma	PD1 inhibitor Resistant: C3 – Early Trials PD1 inhibitor Resistant : C3	PD1 inhibitor Resistant: C3 – Early Trials PD1 inhibitor Resistant : C3
BRAF mutation	Mucosal Melanoma	BRAF mutation	Mucosal Melanoma	cisplatin + dacarbazine Sensitive: C3 – Early Trials cisplatin + dacarbazine Sensitive : C3	cisplatin + dacarbazine Sensitive: C3 – Early Trials cisplatin + dacarbazine Sensitive : C3
NRAS mutation	Mucosal Melanoma	NRAS mutation	Mucosal Melanoma	cisplatin + temozolomide Sensitive: C3 – Early Trials cisplatin + temozolomide Sensitive : C3	cisplatin + temozolomide Sensitive: C3 – Early Trials cisplatin + temozolomide Sensitive : C3
KIT mutation	Mucosal Melanoma	KIT mutation	Mucosal Melanoma	temozolomide Sensitive: C3 – Early Trials temozolomide Sensitive : C3	temozolomide Sensitive: C3 – Early Trials temozolomide Sensitive : C3
BRAF mutation	Mucosal Melanoma	BRAF mutation	Mucosal Melanoma	cisplatin + temozolomide Sensitive: C3 – Early Trials cisplatin + temozolomide Sensitive : C3	cisplatin + temozolomide Sensitive: C3 – Early Trials cisplatin + temozolomide Sensitive : C3
NRAS mutation	Mucosal Melanoma	NRAS mutation	Mucosal Melanoma	cisplatin + dacarbazine Sensitive: C3 – Early Trials cisplatin + dacarbazine Sensitive : C3	cisplatin + dacarbazine Sensitive: C3 – Early Trials cisplatin + dacarbazine Sensitive : C3
KIT mutation	Mucosal Melanoma	KIT mutation	Mucosal Melanoma	cisplatin + dacarbazine Sensitive: C3 – Early Trials cisplatin + dacarbazine Sensitive : C3	cisplatin + dacarbazine Sensitive: C3 – Early Trials cisplatin + dacarbazine Sensitive : C3
PD-L1 expression	Mucosal Melanoma	PD-L1 expression	Mucosal Melanoma	toripalimab Sensitive: C3 – Early Trials toripalimab Sensitive : C3	toripalimab Sensitive: C3 – Early Trials toripalimab Sensitive : C3
KIT exon 17 mutation	Mucosal Melanoma	KIT exon 17 mutation	Mucosal Melanoma	avapritinib Sensitive: C3 – Early Trials avapritinib Sensitive : C3	avapritinib Sensitive: C3 – Early Trials avapritinib Sensitive : C3
KIT L576P	Mucosal Melanoma	KIT L576P	Mucosal Melanoma	sorafenib Resistant: C4 – Case Studies sorafenib Resistant : C4	sorafenib Resistant: C4 – Case Studies sorafenib Resistant : C4
KIT L576P	Mucosal Melanoma	KIT L576P	Mucosal Melanoma	temsirolimus Resistant: C4 – Case Studies temsirolimus Resistant : C4	temsirolimus Resistant: C4 – Case Studies temsirolimus Resistant : C4
KIT L576P	Mucosal Melanoma	KIT L576P	Mucosal Melanoma	imatinib Resistant: C4 – Case Studies imatinib Resistant : C4	imatinib Resistant: C4 – Case Studies imatinib Resistant : C4

Mucosal Melanoma

Associations(29)

Associations
(29)