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Association details:
Biomarker:KIT L576P
Cancer:Mucosal Melanoma
Drug:Torisel (temsirolimus) (mTOR inhibitor)
Direction:Resistant
Evidence:
Evidence Level:
Resistant: C4 – Case Studies
New
Title:

Activity of Dasatinib Against L576P KIT Mutant Melanoma: Molecular, Cellular and Clinical Correlates

Excerpt:
Patient A is a 55 year old woman who had resection of a labial mucosal melanoma…Molecular analysis of a lymph node metastasis identified the presence of a L576P KIT mutation... A repeat biopsy after progression on the sorafenib and temsirolimus regimen confirmed continued presence of the L576P KIT mutation, and failed to identify any secondary mutations in KIT...patient was started on dasatinib 70 mg twice daily. After one month, the patient reported a marked improvement in her symptoms...
DOI:
10.1158/1535-7163.MCT-09-0459