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Association details:
| Biomarker: | KIT L576P |
|---|---|
| Cancer: | Mucosal Melanoma |
| Drug: | imatinib (c-KIT inhibitor, Bcr-abl tyrosine kinase inhibitor, PDGFR inhibitor) |
| Direction: | Resistant |
Evidence:
Source:
Title:
Activity of Dasatinib Against L576P KIT Mutant Melanoma: Molecular, Cellular and Clinical Correlates
Excerpt:
Patient A is a 55 year old woman who had resection of a labial mucosal melanoma…Molecular analysis of a lymph node metastasis identified the presence of a L576P KIT mutation. The patient was then treated with adjuvant imatinib 400 mg daily…lymph node representing a recurrence of melanoma while on imatinib.
DOI:
10.1158/1535-7163.MCT-09-0459
