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BIOMARKER:
MGMT underexpression
i
Other names:
MGMT, Methylated-DNA--protein-cysteine methyltransferase, 6-O-methylguanine-DNA methyltransferase, O-6-methylguanine-DNA-alkyltransferase
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Entrez ID:
4255
Related biomarkers:
Expression
Mutation
CNA
Others
‹
MGMT promoter methylation (16)
MGMT unmethylation (15)
IDH1 mutation + MGMT promoter methylation (1)
IDH2 mutation + MGMT promoter methylation (1)
SETD2 mutation + MGMT promoter methylation (1)
TERT mutation + MGMT promoter methylation (1)
IDH1 mutation + Chr del(1p) + Chr del(19q) + MGMT promoter methylation (0)
IDH2 mutation + Chr del(1p) + Chr del(19q) + MGMT promoter methylation (0)
MGMT promoter methylation (16)
MGMT unmethylation (15)
IDH1 mutation + MGMT promoter methylation (1)
IDH2 mutation + MGMT promoter methylation (1)
SETD2 mutation + MGMT promoter methylation (1)
TERT mutation + MGMT promoter methylation (1)
IDH1 mutation + Chr del(1p) + Chr del(19q) + MGMT promoter methylation (0)
IDH2 mutation + Chr del(1p) + Chr del(19q) + MGMT promoter methylation (0)
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VERI cancer hierarchy
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MGMT underexpression
Glioblastoma
MGMT underexpression
Glioblastoma
temozolomide
Sensitive: C3 – Early Trials
temozolomide
Sensitive
:
C3
temozolomide
Sensitive: C3 – Early Trials
temozolomide
Sensitive
:
C3
MGMT underexpression
Pituitary Gland Carcinoma
MGMT underexpression
Pituitary Gland Carcinoma
temozolomide
Sensitive: C3 – Early Trials
temozolomide
Sensitive
:
C3
temozolomide
Sensitive: C3 – Early Trials
temozolomide
Sensitive
:
C3
MGMT underexpression
Neuroendocrine Tumor
MGMT underexpression
Neuroendocrine Tumor
temozolomide
Sensitive: C3 – Early Trials
temozolomide
Sensitive
:
C3
temozolomide
Sensitive: C3 – Early Trials
temozolomide
Sensitive
:
C3
MGMT underexpression
Colorectal Cancer
MGMT underexpression
Colorectal Cancer
olaparib + temozolomide
Sensitive: C3 – Early Trials
olaparib + temozolomide
Sensitive
:
C3
olaparib + temozolomide
Sensitive: C3 – Early Trials
olaparib + temozolomide
Sensitive
:
C3
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