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    Association details:
    Biomarker:MGMT underexpression
    Cancer:Glioblastoma
    Drug:temozolomide (DNA synthesis inhibitor)
    Direction:Sensitive
    Evidence:
    Evidence Level:
    Sensitive: C3 ā€“ Early Trials
    Source:
    J Neurooncol
    Title:

    Low MGMT digital expression is associated with a better outcome of IDH1 wildtype glioblastomas treated with temozolomide

    Published date:
    01/05/2021
    Excerpt:
    MGMT expression was inversely correlated with MGMTp methylation levels (āˆ’ 0.506, pā€‰<ā€‰0.0001), and MGMT low expression were significantly associated with better patient survival.
    DOI:
    https://doi.org/10.1007/s11060-020-03675-6