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BIOMARKER:
MGMT promoter methylation
i
Other names:
MGMT, Methylated-DNA--protein-cysteine methyltransferase, 6-O-methylguanine-DNA methyltransferase, O-6-methylguanine-DNA-alkyltransferase
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Entrez ID:
4255
Related biomarkers:
Expression
Mutation
CNA
Others
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MGMT promoter methylation
Glioblastoma
MGMT promoter methylation
Glioblastoma
temozolomide
Sensitive: A2 - Guideline
temozolomide
Sensitive
:
A2
temozolomide
Sensitive: A2 - Guideline
temozolomide
Sensitive
:
A2
MGMT promoter methylation
Glioblastoma
MGMT promoter methylation
Glioblastoma
temozolomide + lomustine
Sensitive: A2 - Guideline
temozolomide + lomustine
Sensitive
:
A2
temozolomide + lomustine
Sensitive: A2 - Guideline
temozolomide + lomustine
Sensitive
:
A2
MGMT promoter methylation
Anaplastic Astrocytoma
MGMT promoter methylation
Anaplastic Astrocytoma
temozolomide
Sensitive: B - Late Trials
temozolomide
Sensitive
:
B
temozolomide
Sensitive: B - Late Trials
temozolomide
Sensitive
:
B
MGMT promoter methylation
Ewing Sarcoma
MGMT promoter methylation
Ewing Sarcoma
temozolomide + irinotecan
Sensitive: C2 – Inclusion Criteria
temozolomide + irinotecan
Sensitive
:
C2
temozolomide + irinotecan
Sensitive: C2 – Inclusion Criteria
temozolomide + irinotecan
Sensitive
:
C2
MGMT promoter methylation
Glioblastoma
MGMT promoter methylation
Glioblastoma
cilengitide
Sensitive: C3 – Early Trials
cilengitide
Sensitive
:
C3
cilengitide
Sensitive: C3 – Early Trials
cilengitide
Sensitive
:
C3
MGMT promoter methylation
Glioma
MGMT promoter methylation
Glioma
temozolomide + carmustine
Sensitive: C3 – Early Trials
temozolomide + carmustine
Sensitive
:
C3
temozolomide + carmustine
Sensitive: C3 – Early Trials
temozolomide + carmustine
Sensitive
:
C3
MGMT promoter methylation
Glioblastoma
MGMT promoter methylation
Glioblastoma
ruxolitinib
Sensitive: C3 – Early Trials
ruxolitinib
Sensitive
:
C3
ruxolitinib
Sensitive: C3 – Early Trials
ruxolitinib
Sensitive
:
C3
MGMT promoter methylation
Glioma
MGMT promoter methylation
Glioma
ruxolitinib
Sensitive: C3 – Early Trials
ruxolitinib
Sensitive
:
C3
ruxolitinib
Sensitive: C3 – Early Trials
ruxolitinib
Sensitive
:
C3
MGMT promoter methylation
Glioblastoma
MGMT promoter methylation
Glioblastoma
AV-GBM-1
Sensitive: C3 – Early Trials
AV-GBM-1
Sensitive
:
C3
AV-GBM-1
Sensitive: C3 – Early Trials
AV-GBM-1
Sensitive
:
C3
MGMT promoter methylation
Neuroendocrine Tumor
MGMT promoter methylation
Neuroendocrine Tumor
temozolomide
Sensitive: C3 – Early Trials
temozolomide
Sensitive
:
C3
temozolomide
Sensitive: C3 – Early Trials
temozolomide
Sensitive
:
C3
MGMT promoter methylation
Glioma
MGMT promoter methylation
Glioma
nivolumab + aglatimagene besadenovec
Sensitive: C3 – Early Trials
nivolumab + aglatimagene besadenovec
Sensitive
:
C3
nivolumab + aglatimagene besadenovec
Sensitive: C3 – Early Trials
nivolumab + aglatimagene besadenovec
Sensitive
:
C3
MGMT promoter methylation
Glioblastoma
MGMT promoter methylation
Glioblastoma
regorafenib
Sensitive: C3 – Early Trials
regorafenib
Sensitive
:
C3
regorafenib
Sensitive: C3 – Early Trials
regorafenib
Sensitive
:
C3
MGMT promoter methylation
Colorectal Cancer
MGMT promoter methylation
Colorectal Cancer
FOLFOX
Resistant: C3 – Early Trials
FOLFOX
Resistant
:
C3
FOLFOX
Resistant: C3 – Early Trials
FOLFOX
Resistant
:
C3
MGMT promoter methylation
Glioblastoma
MGMT promoter methylation
Glioblastoma
temozolomide + PAC-1
Sensitive: C3 – Early Trials
temozolomide + PAC-1
Sensitive
:
C3
temozolomide + PAC-1
Sensitive: C3 – Early Trials
temozolomide + PAC-1
Sensitive
:
C3
MGMT promoter methylation
Glioblastoma
MGMT promoter methylation
Glioblastoma
metformin
Sensitive: C3 – Early Trials
metformin
Sensitive
:
C3
metformin
Sensitive: C3 – Early Trials
metformin
Sensitive
:
C3
MGMT promoter methylation
Glioma
MGMT promoter methylation
Glioma
temozolomide + AZD9574
Sensitive: D – Preclinical
temozolomide + AZD9574
Sensitive
:
D
temozolomide + AZD9574
Sensitive: D – Preclinical
temozolomide + AZD9574
Sensitive
:
D
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