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BIOMARKER:
KRAS G12C
i
Other names:
KRAS, KRAS1, KRAS2, Kirsten rat sarcoma viral oncogene homolog
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Entrez ID:
3845
Related biomarkers:
Expression
Mutation
CNA
Others
‹
KRAS mutation (239)
KRAS G12D (64)
KRAS G12V (36)
KRAS wild-type (26)
KRAS G13D (22)
KRAS G12R (18)
RAS wild-type (17)
KRAS G12A (14)
KRAS G12 (10)
KRAS G12S (9)
KRAS G13 (8)
KRAS mutation + STK11 mutation (8)
KRAS Q61H (7)
KRAS exon 2 mutation (7)
TP53 mutation + KRAS mutation (6)
KRAS G12C + STK11 mutation (5)
EGFR mutation + KRAS mutation (4)
KRAS A146 (4)
KRAS A59T (4)
KRAS Q61 (4)
KRAS A146T (3)
KRAS G12C + TP53 mutation (3)
KRAS G12D + STK11 mutation (3)
KRAS Y96D (3)
KRAS Y96S (3)
EGFR T790M + KRAS mutation (2)
EGFR V802I + KRAS mutation (2)
KEAP1 mutation + KRAS mutation (2)
KRAS A146V (2)
KRAS A59 (2)
KRAS A59S (2)
KRAS G12C + KEAP1 mutation (2)
KRAS G12D + KRAS G12V (2)
KRAS G13A (2)
KRAS G13C (2)
KRAS G13D + BRAF mutation (2)
KRAS K117 (2)
KRAS Q99L (2)
KRAS R68M (2)
KRAS exon 12 mutation (2)
KRAS exon 2 wild-type (2)
KRAS exon 3 mutation (2)
KRAS exon 4 mutation (2)
KRAS mutation + EGFR wild-type (2)
KRAS mutation + STK11 mutation + KEAP1 mutation (2)
KRAS mutation + TP53 wild-type (2)
PIK3CA mutation + KRAS mutation (2)
STK11 mutation + KEAP1 mutation + KRAS G12C (2)
ALK rearrangement + EGFR D761N + KRAS V14I (1)
ALK rearrangement + KRAS mutation (1)
APC mutation + KRAS mutation (1)
ARID1A mutation+ KRAS G12C (1)
BRAF V600E + KRAS G12R (1)
DICER1 A1690Gfs*9 + DICER1 E1813Q + KRAS G12L (1)
EGFR T790M + KRAS G12V (1)
KIR2DS4 mutation + KRAS mutation (1)
KRAS G12A + BRAF D549N (1)
KRAS G12C + ATM wild-type (1)
KRAS G12C + KRAS G12V (1)
KRAS G12C + SMARCA4 wild-type (1)
KRAS G12D + DNMT3A C559fsX (1)
KRAS G12V + BRAF V600E (1)
KRAS G12V + STK11 mutation (1)
KRAS G12V + TP53 mutation + APC mutation (1)
KRAS G60D (1)
KRAS G61 (1)
KRAS G61H + KRAS G12A (1)
KRAS N116H (1)
KRAS N116T (1)
KRAS Q22X (1)
KRAS Q61K (1)
KRAS Q61L (1)
KRAS S89P (1)
KRAS V12 (1)
KRAS codon 12 mutation + KRAS codon 13 mutation + EGFR mutation (1)
KRAS exon 13 mutation (1)
KRAS mutation + ATM mutation (1)
KRAS mutation + KEAP1 mutation (1)
KRAS mutation + SMARCA4 mutation (1)
KRAS mutation + STK11 deletion + KEAP1 deletion (1)
KRAS mutation + STK11 mutation + TP53 mutation (1)
KRAS mutation + U2AF1 mutation (1)
KRAS mutation + KMT2C mutation (1)
MAP2K1 G128D + KRAS mutation (1)
MET exon 14 mutation + KRAS G12A (1)
NF1 L581Ffs*6 + KRAS A146P + NRAS Q61K + TP53 R175H + PD-L1 T290M (1)
PIK3CA mutation + PTEN mutation + KRAS mutation (1)
PIK3CA wild-type + KRAS wild-type (1)
PTPN11 mutation + KRAS wild-type (1)
STK11 mutation + KEAP1 mutation + KRAS wild-type (1)
BRAF V600E + KRAS G12D (0)
CDKN2A mutation + CDKN2B mutation + KRAS mutation (0)
CDKN2A mutation + KRAS mutation (0)
KRAS A146P (0)
KRAS A59 (0)
KRAS G61H (0)
KRAS mutation + TP53 mutation (0)
KRAS mutation (239)
KRAS G12D (64)
KRAS G12V (36)
KRAS wild-type (26)
KRAS G13D (22)
KRAS G12R (18)
RAS wild-type (17)
KRAS G12A (14)
KRAS G12 (10)
KRAS G12S (9)
KRAS G13 (8)
KRAS mutation + STK11 mutation (8)
KRAS Q61H (7)
KRAS exon 2 mutation (7)
TP53 mutation + KRAS mutation (6)
KRAS G12C + STK11 mutation (5)
EGFR mutation + KRAS mutation (4)
KRAS A146 (4)
KRAS A59T (4)
KRAS Q61 (4)
KRAS A146T (3)
KRAS G12C + TP53 mutation (3)
KRAS G12D + STK11 mutation (3)
KRAS Y96D (3)
KRAS Y96S (3)
EGFR T790M + KRAS mutation (2)
EGFR V802I + KRAS mutation (2)
KEAP1 mutation + KRAS mutation (2)
KRAS A146V (2)
KRAS A59 (2)
KRAS A59S (2)
KRAS G12C + KEAP1 mutation (2)
KRAS G12D + KRAS G12V (2)
KRAS G13A (2)
KRAS G13C (2)
KRAS G13D + BRAF mutation (2)
KRAS K117 (2)
KRAS Q99L (2)
KRAS R68M (2)
KRAS exon 12 mutation (2)
KRAS exon 2 wild-type (2)
KRAS exon 3 mutation (2)
KRAS exon 4 mutation (2)
KRAS mutation + EGFR wild-type (2)
KRAS mutation + STK11 mutation + KEAP1 mutation (2)
KRAS mutation + TP53 wild-type (2)
PIK3CA mutation + KRAS mutation (2)
STK11 mutation + KEAP1 mutation + KRAS G12C (2)
ALK rearrangement + EGFR D761N + KRAS V14I (1)
ALK rearrangement + KRAS mutation (1)
APC mutation + KRAS mutation (1)
ARID1A mutation+ KRAS G12C (1)
BRAF V600E + KRAS G12R (1)
DICER1 A1690Gfs*9 + DICER1 E1813Q + KRAS G12L (1)
EGFR T790M + KRAS G12V (1)
KIR2DS4 mutation + KRAS mutation (1)
KRAS G12A + BRAF D549N (1)
KRAS G12C + ATM wild-type (1)
KRAS G12C + KRAS G12V (1)
KRAS G12C + SMARCA4 wild-type (1)
KRAS G12D + DNMT3A C559fsX (1)
KRAS G12V + BRAF V600E (1)
KRAS G12V + STK11 mutation (1)
KRAS G12V + TP53 mutation + APC mutation (1)
KRAS G60D (1)
KRAS G61 (1)
KRAS G61H + KRAS G12A (1)
KRAS N116H (1)
KRAS N116T (1)
KRAS Q22X (1)
KRAS Q61K (1)
KRAS Q61L (1)
KRAS S89P (1)
KRAS V12 (1)
KRAS codon 12 mutation + KRAS codon 13 mutation + EGFR mutation (1)
KRAS exon 13 mutation (1)
KRAS mutation + ATM mutation (1)
KRAS mutation + KEAP1 mutation (1)
KRAS mutation + SMARCA4 mutation (1)
KRAS mutation + STK11 deletion + KEAP1 deletion (1)
KRAS mutation + STK11 mutation + TP53 mutation (1)
KRAS mutation + U2AF1 mutation (1)
KRAS mutation + KMT2C mutation (1)
MAP2K1 G128D + KRAS mutation (1)
MET exon 14 mutation + KRAS G12A (1)
NF1 L581Ffs*6 + KRAS A146P + NRAS Q61K + TP53 R175H + PD-L1 T290M (1)
PIK3CA mutation + PTEN mutation + KRAS mutation (1)
PIK3CA wild-type + KRAS wild-type (1)
PTPN11 mutation + KRAS wild-type (1)
STK11 mutation + KEAP1 mutation + KRAS wild-type (1)
BRAF V600E + KRAS G12D (0)
CDKN2A mutation + CDKN2B mutation + KRAS mutation (0)
CDKN2A mutation + KRAS mutation (0)
KRAS A146P (0)
KRAS A59 (0)
KRAS G61H (0)
KRAS mutation + TP53 mutation (0)
›
Related tests:
Guardant360® CDx (54)
therascreen® KRAS RGQ PCR Kit (5)
Resolution ctDx FIRST Assay (1)
Guardant360® CDx (54)
therascreen® KRAS RGQ PCR Kit (5)
Resolution ctDx FIRST Assay (1)
Associations
News
Trials
VERI cancer hierarchy
Reset Filters
KRAS G12C
Non Small Cell Lung Cancer
KRAS G12C
Non Small Cell Lung Cancer
sotorasib
Sensitive: A1 - Approval
sotorasib
Sensitive
:
A1
sotorasib
Sensitive: A1 - Approval
sotorasib
Sensitive
:
A1
KRAS G12C
Non Small Cell Lung Cancer
KRAS G12C
Non Small Cell Lung Cancer
adagrasib
Sensitive: A1 - Approval
adagrasib
Sensitive
:
A1
adagrasib
Sensitive: A1 - Approval
adagrasib
Sensitive
:
A1
KRAS G12C
Colorectal Cancer
KRAS G12C
Colorectal Cancer
adagrasib
Sensitive: A1 - Approval
adagrasib
Sensitive
:
A1
adagrasib
Sensitive: A1 - Approval
adagrasib
Sensitive
:
A1
KRAS G12C
Colorectal Cancer
KRAS G12C
Colorectal Cancer
cetuximab + adagrasib
Sensitive: A1 - Approval
cetuximab + adagrasib
Sensitive
:
A1
cetuximab + adagrasib
Sensitive: A1 - Approval
cetuximab + adagrasib
Sensitive
:
A1
KRAS G12C
Ampulla of Vater Carcinoma
KRAS G12C
Ampulla of Vater Carcinoma
sotorasib
Sensitive: A2 - Guideline
sotorasib
Sensitive
:
A2
sotorasib
Sensitive: A2 - Guideline
sotorasib
Sensitive
:
A2
KRAS G12C
Pancreatic Adenocarcinoma
KRAS G12C
Pancreatic Adenocarcinoma
sotorasib
Sensitive: A2 - Guideline
sotorasib
Sensitive
:
A2
sotorasib
Sensitive: A2 - Guideline
sotorasib
Sensitive
:
A2
KRAS G12C
Pancreatic Adenocarcinoma
KRAS G12C
Pancreatic Adenocarcinoma
adagrasib
Sensitive: A2 - Guideline
adagrasib
Sensitive
:
A2
adagrasib
Sensitive: A2 - Guideline
adagrasib
Sensitive
:
A2
KRAS G12C
Rectal Cancer
KRAS G12C
Rectal Cancer
panitumumab + sotorasib
Sensitive: A2 - Guideline
panitumumab + sotorasib
Sensitive
:
A2
panitumumab + sotorasib
Sensitive: A2 - Guideline
panitumumab + sotorasib
Sensitive
:
A2
KRAS G12C
Rectal Cancer
KRAS G12C
Rectal Cancer
cetuximab + sotorasib
Sensitive: A2 - Guideline
cetuximab + sotorasib
Sensitive
:
A2
cetuximab + sotorasib
Sensitive: A2 - Guideline
cetuximab + sotorasib
Sensitive
:
A2
KRAS G12C
Rectal Cancer
KRAS G12C
Rectal Cancer
panitumumab + adagrasib
Sensitive: A2 - Guideline
panitumumab + adagrasib
Sensitive
:
A2
panitumumab + adagrasib
Sensitive: A2 - Guideline
panitumumab + adagrasib
Sensitive
:
A2
KRAS G12C
Rectal Cancer
KRAS G12C
Rectal Cancer
cetuximab + adagrasib
Sensitive: A2 - Guideline
cetuximab + adagrasib
Sensitive
:
A2
cetuximab + adagrasib
Sensitive: A2 - Guideline
cetuximab + adagrasib
Sensitive
:
A2
KRAS G12C
Colon Cancer
KRAS G12C
Colon Cancer
panitumumab + sotorasib
Sensitive: A2 - Guideline
panitumumab + sotorasib
Sensitive
:
A2
panitumumab + sotorasib
Sensitive: A2 - Guideline
panitumumab + sotorasib
Sensitive
:
A2
KRAS G12C
Colon Cancer
KRAS G12C
Colon Cancer
cetuximab + sotorasib
Sensitive: A2 - Guideline
cetuximab + sotorasib
Sensitive
:
A2
cetuximab + sotorasib
Sensitive: A2 - Guideline
cetuximab + sotorasib
Sensitive
:
A2
KRAS G12C
Colon Cancer
KRAS G12C
Colon Cancer
cetuximab + adagrasib
Sensitive: A2 - Guideline
cetuximab + adagrasib
Sensitive
:
A2
cetuximab + adagrasib
Sensitive: A2 - Guideline
cetuximab + adagrasib
Sensitive
:
A2
KRAS G12C
Colon Cancer
KRAS G12C
Colon Cancer
panitumumab + adagrasib
Sensitive: A2 - Guideline
panitumumab + adagrasib
Sensitive
:
A2
panitumumab + adagrasib
Sensitive: A2 - Guideline
panitumumab + adagrasib
Sensitive
:
A2
KRAS G12C
Ampulla of Vater Carcinoma
KRAS G12C
Ampulla of Vater Carcinoma
adagrasib
Sensitive: A2 - Guideline
adagrasib
Sensitive
:
A2
adagrasib
Sensitive: A2 - Guideline
adagrasib
Sensitive
:
A2
KRAS G12C
Non Small Cell Lung Cancer
KRAS G12C
Non Small Cell Lung Cancer
Immunotherapy
Sensitive: B - Late Trials
Immunotherapy
Sensitive
:
B
Immunotherapy
Sensitive: B - Late Trials
Immunotherapy
Sensitive
:
B
KRAS G12C
Lung Non-Squamous Non-Small Cell Cancer
KRAS G12C
Lung Non-Squamous Non-Small Cell Cancer
Immunotherapy
Sensitive: B - Late Trials
Immunotherapy
Sensitive
:
B
Immunotherapy
Sensitive: B - Late Trials
Immunotherapy
Sensitive
:
B
KRAS G12C
Non Small Cell Lung Cancer
KRAS G12C
Non Small Cell Lung Cancer
abemaciclib
Sensitive: B - Late Trials
abemaciclib
Sensitive
:
B
abemaciclib
Sensitive: B - Late Trials
abemaciclib
Sensitive
:
B
KRAS G12C
Non Small Cell Lung Cancer
KRAS G12C
Non Small Cell Lung Cancer
pembrolizumab
Sensitive: B - Late Trials
pembrolizumab
Sensitive
:
B
pembrolizumab
Sensitive: B - Late Trials
pembrolizumab
Sensitive
:
B
KRAS G12C
Colorectal Cancer
KRAS G12C
Colorectal Cancer
cetuximab
Resistant: B - Late Trials
cetuximab
Resistant
:
B
cetuximab
Resistant: B - Late Trials
cetuximab
Resistant
:
B
KRAS G12C
Colorectal Cancer
KRAS G12C
Colorectal Cancer
panitumumab
Resistant: B - Late Trials
panitumumab
Resistant
:
B
panitumumab
Resistant: B - Late Trials
panitumumab
Resistant
:
B
KRAS G12C
Colorectal Cancer
KRAS G12C
Colorectal Cancer
panitumumab + sotorasib
Sensitive: B - Late Trials
panitumumab + sotorasib
Sensitive
:
B
panitumumab + sotorasib
Sensitive: B - Late Trials
panitumumab + sotorasib
Sensitive
:
B
KRAS G12C
Non Small Cell Lung Cancer
KRAS G12C
Non Small Cell Lung Cancer
sotorasib + BMS-986466
Sensitive: B - Late Trials
sotorasib + BMS-986466
Sensitive
:
B
sotorasib + BMS-986466
Sensitive: B - Late Trials
sotorasib + BMS-986466
Sensitive
:
B
KRAS G12C
Pancreatic Cancer
KRAS G12C
Pancreatic Cancer
JAB-21822
Sensitive: B - Late Trials
JAB-21822
Sensitive
:
B
JAB-21822
Sensitive: B - Late Trials
JAB-21822
Sensitive
:
B
KRAS G12C
Pancreatic Cancer
KRAS G12C
Pancreatic Cancer
sotorasib
Sensitive: C1 - Off-label
sotorasib
Sensitive
:
C1
sotorasib
Sensitive: C1 - Off-label
sotorasib
Sensitive
:
C1
KRAS G12C
Cholangiocarcinoma
KRAS G12C
Cholangiocarcinoma
adagrasib
Sensitive: C1 - Off-label
adagrasib
Sensitive
:
C1
adagrasib
Sensitive: C1 - Off-label
adagrasib
Sensitive
:
C1
KRAS G12C
Ovarian Cancer
KRAS G12C
Ovarian Cancer
adagrasib
Sensitive: C1 - Off-label
adagrasib
Sensitive
:
C1
adagrasib
Sensitive: C1 - Off-label
adagrasib
Sensitive
:
C1
KRAS G12C
Pancreatic Cancer
KRAS G12C
Pancreatic Cancer
adagrasib
Sensitive: C1 - Off-label
adagrasib
Sensitive
:
C1
adagrasib
Sensitive: C1 - Off-label
adagrasib
Sensitive
:
C1
KRAS G12C
Endometrial Cancer
KRAS G12C
Endometrial Cancer
adagrasib
Sensitive: C1 - Off-label
adagrasib
Sensitive
:
C1
adagrasib
Sensitive: C1 - Off-label
adagrasib
Sensitive
:
C1
KRAS G12C
Melanoma
KRAS G12C
Melanoma
sotorasib
Sensitive: C1 - Off-label
sotorasib
Sensitive
:
C1
sotorasib
Sensitive: C1 - Off-label
sotorasib
Sensitive
:
C1
KRAS G12C
Endometrial Cancer
KRAS G12C
Endometrial Cancer
sotorasib
Sensitive: C1 - Off-label
sotorasib
Sensitive
:
C1
sotorasib
Sensitive: C1 - Off-label
sotorasib
Sensitive
:
C1
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