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BIOMARKER:

KRAS G12

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Entrez ID:

Related biomarkers:

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KRAS mutation (239)

KRAS G12C (159)

KRAS wild-type (26)

RAS wild-type (17)

KRAS mutation + STK11 mutation (8)

KRAS exon 2 mutation (7)

TP53 mutation + KRAS mutation (6)

KRAS G12C + STK11 mutation (5)

EGFR mutation + KRAS mutation (4)

KRAS G12C + TP53 mutation (3)

KRAS G12D + STK11 mutation (3)

EGFR T790M + KRAS mutation (2)

EGFR V802I + KRAS mutation (2)

KEAP1 mutation + KRAS mutation (2)

KRAS G12C + KEAP1 mutation (2)

KRAS G12D + KRAS G12V (2)

KRAS G13D + BRAF mutation (2)

KRAS exon 12 mutation (2)

KRAS exon 2 wild-type (2)

KRAS exon 3 mutation (2)

KRAS exon 4 mutation (2)

KRAS mutation + EGFR wild-type (2)

KRAS mutation + STK11 mutation + KEAP1 mutation (2)

KRAS mutation + TP53 wild-type (2)

PIK3CA mutation + KRAS mutation (2)

STK11 mutation + KEAP1 mutation + KRAS G12C (2)

ALK rearrangement + EGFR D761N + KRAS V14I (1)

ALK rearrangement + KRAS mutation (1)

APC mutation + KRAS mutation (1)

ARID1A mutation+ KRAS G12C (1)

BRAF V600E + KRAS G12R (1)

DICER1 A1690Gfs*9 + DICER1 E1813Q + KRAS G12L (1)

EGFR T790M + KRAS G12V (1)

KIR2DS4 mutation + KRAS mutation (1)

KRAS G12A + BRAF D549N (1)

KRAS G12C + ATM wild-type (1)

KRAS G12C + KRAS G12V (1)

KRAS G12C + SMARCA4 wild-type (1)

KRAS G12D + DNMT3A C559fsX (1)

KRAS G12V + BRAF V600E (1)

KRAS G12V + STK11 mutation (1)

KRAS G12V + TP53 mutation + APC mutation (1)

KRAS G61H + KRAS G12A (1)

KRAS codon 12 mutation + KRAS codon 13 mutation + EGFR mutation (1)

KRAS exon 13 mutation (1)

KRAS mutation + ATM mutation (1)

KRAS mutation + KEAP1 mutation (1)

KRAS mutation + SMARCA4 mutation (1)

KRAS mutation + STK11 deletion + KEAP1 deletion (1)

KRAS mutation + STK11 mutation + TP53 mutation (1)

KRAS mutation + U2AF1 mutation (1)

KRAS mutation + KMT2C mutation (1)

MAP2K1 G128D + KRAS mutation (1)

MET exon 14 mutation + KRAS G12A (1)

NF1 L581Ffs*6 + KRAS A146P + NRAS Q61K + TP53 R175H + PD-L1 T290M (1)

PIK3CA mutation + PTEN mutation + KRAS mutation (1)

PIK3CA wild-type + KRAS wild-type (1)

PTPN11 mutation + KRAS wild-type (1)

STK11 mutation + KEAP1 mutation + KRAS wild-type (1)

BRAF V600E + KRAS G12D (0)

CDKN2A mutation + CDKN2B mutation + KRAS mutation (0)

CDKN2A mutation + KRAS mutation (0)

KRAS mutation + TP53 mutation (0)

KRAS mutation (239)

KRAS G12C (159)

KRAS wild-type (26)

RAS wild-type (17)

KRAS mutation + STK11 mutation (8)

KRAS exon 2 mutation (7)

TP53 mutation + KRAS mutation (6)

KRAS G12C + STK11 mutation (5)

EGFR mutation + KRAS mutation (4)

KRAS G12C + TP53 mutation (3)

KRAS G12D + STK11 mutation (3)

EGFR T790M + KRAS mutation (2)

EGFR V802I + KRAS mutation (2)

KEAP1 mutation + KRAS mutation (2)

KRAS G12C + KEAP1 mutation (2)

KRAS G12D + KRAS G12V (2)

KRAS G13D + BRAF mutation (2)

KRAS exon 12 mutation (2)

KRAS exon 2 wild-type (2)

KRAS exon 3 mutation (2)

KRAS exon 4 mutation (2)

KRAS mutation + EGFR wild-type (2)

KRAS mutation + STK11 mutation + KEAP1 mutation (2)

KRAS mutation + TP53 wild-type (2)

PIK3CA mutation + KRAS mutation (2)

STK11 mutation + KEAP1 mutation + KRAS G12C (2)

ALK rearrangement + EGFR D761N + KRAS V14I (1)

ALK rearrangement + KRAS mutation (1)

APC mutation + KRAS mutation (1)

ARID1A mutation+ KRAS G12C (1)

BRAF V600E + KRAS G12R (1)

DICER1 A1690Gfs*9 + DICER1 E1813Q + KRAS G12L (1)

EGFR T790M + KRAS G12V (1)

KIR2DS4 mutation + KRAS mutation (1)

KRAS G12A + BRAF D549N (1)

KRAS G12C + ATM wild-type (1)

KRAS G12C + KRAS G12V (1)

KRAS G12C + SMARCA4 wild-type (1)

KRAS G12D + DNMT3A C559fsX (1)

KRAS G12V + BRAF V600E (1)

KRAS G12V + STK11 mutation (1)

KRAS G12V + TP53 mutation + APC mutation (1)

KRAS G61H + KRAS G12A (1)

KRAS codon 12 mutation + KRAS codon 13 mutation + EGFR mutation (1)

KRAS exon 13 mutation (1)

KRAS mutation + ATM mutation (1)

KRAS mutation + KEAP1 mutation (1)

KRAS mutation + SMARCA4 mutation (1)

KRAS mutation + STK11 deletion + KEAP1 deletion (1)

KRAS mutation + STK11 mutation + TP53 mutation (1)

KRAS mutation + U2AF1 mutation (1)

KRAS mutation + KMT2C mutation (1)

MAP2K1 G128D + KRAS mutation (1)

MET exon 14 mutation + KRAS G12A (1)

NF1 L581Ffs*6 + KRAS A146P + NRAS Q61K + TP53 R175H + PD-L1 T290M (1)

PIK3CA mutation + PTEN mutation + KRAS mutation (1)

PIK3CA wild-type + KRAS wild-type (1)

PTPN11 mutation + KRAS wild-type (1)

STK11 mutation + KEAP1 mutation + KRAS wild-type (1)

BRAF V600E + KRAS G12D (0)

CDKN2A mutation + CDKN2B mutation + KRAS mutation (0)

CDKN2A mutation + KRAS mutation (0)

KRAS mutation + TP53 mutation (0)

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KRAS G12	Colorectal Cancer	KRAS G12	Colorectal Cancer	cetuximab Resistant: A1 - Approval cetuximab Resistant : A1	cetuximab Resistant: A1 - Approval cetuximab Resistant : A1
KRAS G12	Colorectal Cancer	KRAS G12	Colorectal Cancer	trifluridine/tipiracil Resistant: B - Late Trials trifluridine / tipiracil Resistant : B	trifluridine/tipiracil Resistant: B - Late Trials trifluridine / tipiracil Resistant : B
KRAS G12	Ovarian Cancer	KRAS G12	Ovarian Cancer	cetuximab Resistant: C1 - Off-label cetuximab Resistant : C1	cetuximab Resistant: C1 - Off-label cetuximab Resistant : C1
KRAS G12	Non Small Cell Lung Cancer	KRAS G12	Non Small Cell Lung Cancer	RMC-6236 Sensitive: C2 – Inclusion Criteria RMC-6236 Sensitive : C2	RMC-6236 Sensitive: C2 – Inclusion Criteria RMC-6236 Sensitive : C2
KRAS G12	Colorectal Cancer	KRAS G12	Colorectal Cancer	bevacizumab Sensitive: C3 – Early Trials bevacizumab Sensitive : C3	bevacizumab Sensitive: C3 – Early Trials bevacizumab Sensitive : C3
KRAS G12	Colorectal Cancer	KRAS G12	Colorectal Cancer	AZD1775 Sensitive: C3 – Early Trials AZD1775 Sensitive : C3	AZD1775 Sensitive: C3 – Early Trials AZD1775 Sensitive : C3
KRAS G12	Pancreatic Ductal Adenocarcinoma	KRAS G12	Pancreatic Ductal Adenocarcinoma	RMC-6236 Sensitive: C3 – Early Trials RMC-6236 Sensitive : C3	RMC-6236 Sensitive: C3 – Early Trials RMC-6236 Sensitive : C3
KRAS G12	Colorectal Cancer	KRAS G12	Colorectal Cancer	RTB101 Sensitive: D – Preclinical RTB101 Sensitive : D	RTB101 Sensitive: D – Preclinical RTB101 Sensitive : D
KRAS G12	Colorectal Cancer	KRAS G12	Colorectal Cancer	selumetinib + RTB101 Sensitive: D – Preclinical selumetinib + RTB101 Sensitive : D	selumetinib + RTB101 Sensitive: D – Preclinical selumetinib + RTB101 Sensitive : D
KRAS G12	Colorectal Cancer	KRAS G12	Colorectal Cancer	selumetinib Sensitive: D – Preclinical selumetinib Sensitive : D	selumetinib Sensitive: D – Preclinical selumetinib Sensitive : D