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BIOMARKER:
ER Y537S
i
Other names:
ESR1, Era, ESR, NR3A1, ER, ER beta
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Entrez ID:
2099
Related biomarkers:
Expression
Mutation
CNA
Fusion
Others
‹
ER positive (199)
HR positive (184)
HR negative (25)
ER negative (13)
ER positive + PGR positive (12)
HR positive + HER-2 negative (5)
ER expression (3)
ER overexpression (3)
IRF8 overexpression + ER negative (3)
ER positive + HER-2 negative (2)
ER positive + PGR negative (2)
FGFR1 overexpression + HR positive (2)
HR negative + PD-L1 expression (2)
HR positive + ER overexpression (2)
HR positive + HER-2 underexpression (2)
AR positive + ER positive (1)
CETN2 overexpression + HR positive (1)
CETN2 overexpression + MLH3 overexpression + PCNA overexpression + HR positive (1)
CTSD positive + ER positive (1)
ER negative + HER-2 negative (1)
ER positive + CDK6 overexpression (1)
ER positive + PGR negative + HER-2 negative (1)
ER underexpression (1)
HDC overexpression + HR positive (1)
HER-2 underexpression + ER underexpression (1)
HR overexpression (1)
HR positive + AR positive (1)
HR positive + BRCA positive (1)
HR positive + CCNE1 overexpression (1)
HR positive + ERBB3 overexpression (1)
HR positive + ERBB3 underexpression (1)
HR positive + HER-2 positive (1)
HR positive + PD-L1 expression (1)
HR positive + PLK1 overexpression (1)
HR positive + TNFRSF11A overexpression (1)
MLH3 overexpression + HR positive (1)
NOTCH3 expression + ER positive + PGR positive (1)
PCNA overexpression + HR positive (1)
PD-L1 overexpression + ER positive (1)
RAD51 overexpression + HR positive (1)
RFC3 overexpression + ER positive (1)
TFF1 overexpression + ER positive (1)
TFF3 overexpression + ER positive (1)
TNFRSF1A overexpression + HR positive (1)
TYMS overexpression + HR positive (1)
BIN3 expression + ER positive (0)
CCNA2 expression + ER positive (0)
CCNB2 expression + ER positive (0)
CTDSP1 expression + ER positive (0)
EPRS1 expression + ER positive (0)
ER negative + HER-2 positive (0)
ER negative + PGR positive (0)
ER positive + HER-2 positive (0)
ER positive + PGR positive + HER-2 positive (0)
FOXD1 expression + ER positive (0)
FTO expression + ER positive (0)
HER-2 negative + AR positive + ER positive (0)
HER-2 negative + ER positive (0)
HR negative + HER-2 positive (0)
MIEN1 expression + ER negative + PR negative (0)
NCOR2 overexpression + ER positive (0)
RBPMS expression + ER positive (0)
SLBP expression + ER positive (0)
WSB2 expression + ER positive (0)
ER positive (199)
HR positive (184)
HR negative (25)
ER negative (13)
ER positive + PGR positive (12)
HR positive + HER-2 negative (5)
ER expression (3)
ER overexpression (3)
IRF8 overexpression + ER negative (3)
ER positive + HER-2 negative (2)
ER positive + PGR negative (2)
FGFR1 overexpression + HR positive (2)
HR negative + PD-L1 expression (2)
HR positive + ER overexpression (2)
HR positive + HER-2 underexpression (2)
AR positive + ER positive (1)
CETN2 overexpression + HR positive (1)
CETN2 overexpression + MLH3 overexpression + PCNA overexpression + HR positive (1)
CTSD positive + ER positive (1)
ER negative + HER-2 negative (1)
ER positive + CDK6 overexpression (1)
ER positive + PGR negative + HER-2 negative (1)
ER underexpression (1)
HDC overexpression + HR positive (1)
HER-2 underexpression + ER underexpression (1)
HR overexpression (1)
HR positive + AR positive (1)
HR positive + BRCA positive (1)
HR positive + CCNE1 overexpression (1)
HR positive + ERBB3 overexpression (1)
HR positive + ERBB3 underexpression (1)
HR positive + HER-2 positive (1)
HR positive + PD-L1 expression (1)
HR positive + PLK1 overexpression (1)
HR positive + TNFRSF11A overexpression (1)
MLH3 overexpression + HR positive (1)
NOTCH3 expression + ER positive + PGR positive (1)
PCNA overexpression + HR positive (1)
PD-L1 overexpression + ER positive (1)
RAD51 overexpression + HR positive (1)
RFC3 overexpression + ER positive (1)
TFF1 overexpression + ER positive (1)
TFF3 overexpression + ER positive (1)
TNFRSF1A overexpression + HR positive (1)
TYMS overexpression + HR positive (1)
BIN3 expression + ER positive (0)
CCNA2 expression + ER positive (0)
CCNB2 expression + ER positive (0)
CTDSP1 expression + ER positive (0)
EPRS1 expression + ER positive (0)
ER negative + HER-2 positive (0)
ER negative + PGR positive (0)
ER positive + HER-2 positive (0)
ER positive + PGR positive + HER-2 positive (0)
FOXD1 expression + ER positive (0)
FTO expression + ER positive (0)
HER-2 negative + AR positive + ER positive (0)
HER-2 negative + ER positive (0)
HR negative + HER-2 positive (0)
MIEN1 expression + ER negative + PR negative (0)
NCOR2 overexpression + ER positive (0)
RBPMS expression + ER positive (0)
SLBP expression + ER positive (0)
WSB2 expression + ER positive (0)
›
Associations
News
Trials
VERI cancer hierarchy
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ER Y537S
HER2 Negative Breast Cancer
ER Y537S
HER2 Negative Breast Cancer
H3B-6545
Sensitive: C2 – Inclusion Criteria
H3B-6545
Sensitive
:
C2
H3B-6545
Sensitive: C2 – Inclusion Criteria
H3B-6545
Sensitive
:
C2
ER Y537S
HER2 Negative Breast Cancer
ER Y537S
HER2 Negative Breast Cancer
SAR439859
Sensitive: C3 – Early Trials
SAR439859
Sensitive
:
C3
SAR439859
Sensitive: C3 – Early Trials
SAR439859
Sensitive
:
C3
ER Y537S
Estrogen Receptor Positive Breast Cancer
ER Y537S
Estrogen Receptor Positive Breast Cancer
fulvestrant
Sensitive: C3 – Early Trials
fulvestrant
Sensitive
:
C3
fulvestrant
Sensitive: C3 – Early Trials
fulvestrant
Sensitive
:
C3
ER Y537S
HER2 Negative Breast Cancer
ER Y537S
HER2 Negative Breast Cancer
palbociclib + PF-05212384
Sensitive: C3 – Early Trials
palbociclib + PF-05212384
Sensitive
:
C3
palbociclib + PF-05212384
Sensitive: C3 – Early Trials
palbociclib + PF-05212384
Sensitive
:
C3
ER Y537S
Breast Cancer
ER Y537S
Breast Cancer
tamoxifen
Sensitive: C4 – Case Studies
tamoxifen
Sensitive
:
C4
tamoxifen
Sensitive: C4 – Case Studies
tamoxifen
Sensitive
:
C4
ER Y537S
Estrogen Receptor Positive Breast Cancer
ER Y537S
Estrogen Receptor Positive Breast Cancer
SAR439859
Sensitive: D – Preclinical
SAR439859
Sensitive
:
D
SAR439859
Sensitive: D – Preclinical
SAR439859
Sensitive
:
D
ER Y537S
Estrogen Receptor Positive Breast Cancer
ER Y537S
Estrogen Receptor Positive Breast Cancer
OP-1250
Sensitive: D – Preclinical
OP-1250
Sensitive
:
D
OP-1250
Sensitive: D – Preclinical
OP-1250
Sensitive
:
D
ER Y537S
Breast Cancer
ER Y537S
Breast Cancer
OP-1250
Sensitive: D – Preclinical
OP-1250
Sensitive
:
D
OP-1250
Sensitive: D – Preclinical
OP-1250
Sensitive
:
D
ER Y537S
Breast Cancer
ER Y537S
Breast Cancer
ZN-c5
Sensitive: D – Preclinical
ZN-c5
Sensitive
:
D
ZN-c5
Sensitive: D – Preclinical
ZN-c5
Sensitive
:
D
ER Y537S
Estrogen Receptor Positive Breast Cancer
ER Y537S
Estrogen Receptor Positive Breast Cancer
lasofoxifene
Sensitive: D – Preclinical
lasofoxifene
Sensitive
:
D
lasofoxifene
Sensitive: D – Preclinical
lasofoxifene
Sensitive
:
D
ER Y537S
Breast Cancer
ER Y537S
Breast Cancer
LY3484356
Sensitive: D – Preclinical
LY3484356
Sensitive
:
D
LY3484356
Sensitive: D – Preclinical
LY3484356
Sensitive
:
D
ER Y537S
Estrogen Receptor Positive Breast Cancer
ER Y537S
Estrogen Receptor Positive Breast Cancer
GDC-9545
Sensitive: D – Preclinical
GDC-9545
Sensitive
:
D
GDC-9545
Sensitive: D – Preclinical
GDC-9545
Sensitive
:
D
ER Y537S
Estrogen Receptor Positive Breast Cancer
ER Y537S
Estrogen Receptor Positive Breast Cancer
palbociclib + OP-1250
Sensitive: D – Preclinical
palbociclib + OP-1250
Sensitive
:
D
palbociclib + OP-1250
Sensitive: D – Preclinical
palbociclib + OP-1250
Sensitive
:
D
ER Y537S
Estrogen Receptor Positive Breast Cancer
ER Y537S
Estrogen Receptor Positive Breast Cancer
palbociclib
Sensitive: D – Preclinical
palbociclib
Sensitive
:
D
palbociclib
Sensitive: D – Preclinical
palbociclib
Sensitive
:
D
ER Y537S
Breast Cancer
ER Y537S
Breast Cancer
CB-103
Sensitive: D – Preclinical
CB-103
Sensitive
:
D
CB-103
Sensitive: D – Preclinical
CB-103
Sensitive
:
D
ER Y537S
Estrogen Receptor Positive Breast Cancer
ER Y537S
Estrogen Receptor Positive Breast Cancer
SCR-6852
Sensitive: D – Preclinical
SCR-6852
Sensitive
:
D
SCR-6852
Sensitive: D – Preclinical
SCR-6852
Sensitive
:
D
ER Y537S
Estrogen Receptor Positive Breast Cancer
ER Y537S
Estrogen Receptor Positive Breast Cancer
KPT-8602
Sensitive: D – Preclinical
KPT-8602
Sensitive
:
D
KPT-8602
Sensitive: D – Preclinical
KPT-8602
Sensitive
:
D
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