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BIOMARKER:
ER positive
i
Other names:
ESR1, Era, ESR, NR3A1, ER, ER beta
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to learn more about our Premium Content:
News alerts, weekly reports and conference planners
Entrez ID:
2099
Related biomarkers:
Expression
Mutation
CNA
Fusion
Others
‹
PIK3CA mutation + HR positive (16)
PIK3CA mutation + ER positive (10)
ESR1 mutation + HR positive (6)
ESR1 wild-type + HR positive (4)
BRCA1 mutation + HR positive (3)
BRCA2 mutation + HR positive (3)
ER positive + PIK3CA H1047R (3)
FGFR1 amplification + HR positive (3)
HR positive + BRCA2 mutation (3)
HR-positive + PIK3CA wild-type (3)
PIK3CA exon 20 mutation + HR positive (3)
AKT1 E17K + HR positive (2)
AKT1 mutation + ER positive (2)
AKT1 mutation + HR positive (2)
ER Y537S + ER positive (2)
ER positive + TP53 mutation (2)
ER-L (2)
HR negative + BRCA1 mutation (2)
HR negative + BRCA2 mutation (2)
HR positive + BRCA1 mutation (2)
HR positive + MYC amplification (2)
HR positive + TP53 mutation (2)
PIK3CA mutation + ER negative (2)
PTEN deletion + ER positive (2)
AKT1 mutation + ER negative (1)
BRCA1 mutation + HER-2 negative + ER positive + PGR positive (1)
BRCA2 mutation + ER positive (1)
BRCA2 mutation + ER positive + PGR positive (1)
CCND1 mutation + HR positive (1)
CCND2 mutation + HR positive (1)
CCNE1 overexpression + PIK3CA muattion + ER positive (1)
CCNE2 overexpression + PIK3CA mutation + ER positive (1)
CDK4 mutation + HR positive (1)
CDKN1B mutation + HR positive (1)
EGFR mutation + ER positive (1)
ER D538G + ER positive (1)
ER E380Q + ER positive (1)
ER L536H + ER D538G + CCND1 amplification (1)
ER Y537N + ER positive (1)
ER negative + HER-2 positive + PGR positive + PIK3CA mutation (1)
ER positive + ESR1 mutation + CCND1 amplification (1)
ER positive + ESR1 mutation + FGFR1 amplification (1)
ER positive + ESR1 mutation + PIK3CA mutation (1)
ER positive + ESR1 mutation + TP53 mutation (1)
ER positive + FGFR1 amplification (1)
ER positive + FGFR3 amplification (1)
ER positive + HER-2 D769H + HER-2 V777L (1)
ER positive + MLH1 1835del3 + MSI-H/dMMR + TMB-H (1)
ER positive + ZNF217 overexpression (1)
ER underexpression + ER Y537S (1)
ERBB4 H809G + ER positive (1)
ESR1 mutation + PIK3CA mutation + HR positive (1)
FGF19 amplification + ER positive (1)
FGF3 amplification + ER positive (1)
FGF4 amplification + ER positive (1)
FOXA1 expression + ER positive (1)
HER-2 amplification + ER positive + PGR negative (1)
HR negative + EGFR amplification (1)
HR positive + APOBEC signature (1)
HR positive + AURKA amplification (1)
HR positive + AURKA mutation (1)
HR positive + BRAF V600E (1)
HR positive + BRCA1 mutation + PALB2 mutation (1)
HR positive + BRCA2 mutation + PALB2 mutation (1)
HR positive + BRIP1 amplification (1)
HR positive + CCND1 amplification (1)
HR positive + HER-2 amplification (1)
HR positive + HER-2 mutation (1)
HR positive + MYC mutation (1)
HR positive + PIK3CA exon 10 mutation (1)
HR positive + PTEN deletion (1)
HR positive + RAD51C amplification (1)
HR positive + RB1 mutation (1)
HR positive + TMB-H (1)
HR positive + TMB-L (1)
High HDAC6 score + HR positive (1)
KRAS mutation + CDK9 overexpression + HR positive (1)
KRAS mutation + ER expression (1)
KRAS mutation + HR positive (1)
MTOR mutation + HR positive (1)
MYC mutation + ER positive (1)
PIK3CA E542K + HR positive (1)
PIK3CA amplification + PIK3CA mutation + HR positive (1)
PIK3CA exon 7 mutation + HR positive (1)
PIK3CA exon 9 mutation + HR positive (1)
PIK3CA mutation + ESR1 wild-type (1)
PIK3CA mutation + HR positive + HER-2 negative (1)
PIK3CA wild-type+ ESR1 wild-type (1)
PTEN mutation + HR positive (1)
TP53 wild-type + ER positive (1)
AKT1 E17K + CTNNB1 G34R + ER Y537S + MSI-H (0)
ER negative + HER-2 positive + PIK3CA H1047R (0)
ER positive + BRCA1 mutation (0)
ER positive + BRCA2 mutation (0)
ER positive + HER-2 negative + ER mutation (0)
HR positive + HER-2 negative + TMB-L (0)
PIK3CA mutation + ER negative + PGR positive (0)
PIK3CA mutation + HR positive (16)
PIK3CA mutation + ER positive (10)
ESR1 mutation + HR positive (6)
ESR1 wild-type + HR positive (4)
BRCA1 mutation + HR positive (3)
BRCA2 mutation + HR positive (3)
ER positive + PIK3CA H1047R (3)
FGFR1 amplification + HR positive (3)
HR positive + BRCA2 mutation (3)
HR-positive + PIK3CA wild-type (3)
PIK3CA exon 20 mutation + HR positive (3)
AKT1 E17K + HR positive (2)
AKT1 mutation + ER positive (2)
AKT1 mutation + HR positive (2)
ER Y537S + ER positive (2)
ER positive + TP53 mutation (2)
ER-L (2)
HR negative + BRCA1 mutation (2)
HR negative + BRCA2 mutation (2)
HR positive + BRCA1 mutation (2)
HR positive + MYC amplification (2)
HR positive + TP53 mutation (2)
PIK3CA mutation + ER negative (2)
PTEN deletion + ER positive (2)
AKT1 mutation + ER negative (1)
BRCA1 mutation + HER-2 negative + ER positive + PGR positive (1)
BRCA2 mutation + ER positive (1)
BRCA2 mutation + ER positive + PGR positive (1)
CCND1 mutation + HR positive (1)
CCND2 mutation + HR positive (1)
CCNE1 overexpression + PIK3CA muattion + ER positive (1)
CCNE2 overexpression + PIK3CA mutation + ER positive (1)
CDK4 mutation + HR positive (1)
CDKN1B mutation + HR positive (1)
EGFR mutation + ER positive (1)
ER D538G + ER positive (1)
ER E380Q + ER positive (1)
ER L536H + ER D538G + CCND1 amplification (1)
ER Y537N + ER positive (1)
ER negative + HER-2 positive + PGR positive + PIK3CA mutation (1)
ER positive + ESR1 mutation + CCND1 amplification (1)
ER positive + ESR1 mutation + FGFR1 amplification (1)
ER positive + ESR1 mutation + PIK3CA mutation (1)
ER positive + ESR1 mutation + TP53 mutation (1)
ER positive + FGFR1 amplification (1)
ER positive + FGFR3 amplification (1)
ER positive + HER-2 D769H + HER-2 V777L (1)
ER positive + MLH1 1835del3 + MSI-H/dMMR + TMB-H (1)
ER positive + ZNF217 overexpression (1)
ER underexpression + ER Y537S (1)
ERBB4 H809G + ER positive (1)
ESR1 mutation + PIK3CA mutation + HR positive (1)
FGF19 amplification + ER positive (1)
FGF3 amplification + ER positive (1)
FGF4 amplification + ER positive (1)
FOXA1 expression + ER positive (1)
HER-2 amplification + ER positive + PGR negative (1)
HR negative + EGFR amplification (1)
HR positive + APOBEC signature (1)
HR positive + AURKA amplification (1)
HR positive + AURKA mutation (1)
HR positive + BRAF V600E (1)
HR positive + BRCA1 mutation + PALB2 mutation (1)
HR positive + BRCA2 mutation + PALB2 mutation (1)
HR positive + BRIP1 amplification (1)
HR positive + CCND1 amplification (1)
HR positive + HER-2 amplification (1)
HR positive + HER-2 mutation (1)
HR positive + MYC mutation (1)
HR positive + PIK3CA exon 10 mutation (1)
HR positive + PTEN deletion (1)
HR positive + RAD51C amplification (1)
HR positive + RB1 mutation (1)
HR positive + TMB-H (1)
HR positive + TMB-L (1)
High HDAC6 score + HR positive (1)
KRAS mutation + CDK9 overexpression + HR positive (1)
KRAS mutation + ER expression (1)
KRAS mutation + HR positive (1)
MTOR mutation + HR positive (1)
MYC mutation + ER positive (1)
PIK3CA E542K + HR positive (1)
PIK3CA amplification + PIK3CA mutation + HR positive (1)
PIK3CA exon 7 mutation + HR positive (1)
PIK3CA exon 9 mutation + HR positive (1)
PIK3CA mutation + ESR1 wild-type (1)
PIK3CA mutation + HR positive + HER-2 negative (1)
PIK3CA wild-type+ ESR1 wild-type (1)
PTEN mutation + HR positive (1)
TP53 wild-type + ER positive (1)
AKT1 E17K + CTNNB1 G34R + ER Y537S + MSI-H (0)
ER negative + HER-2 positive + PIK3CA H1047R (0)
ER positive + BRCA1 mutation (0)
ER positive + BRCA2 mutation (0)
ER positive + HER-2 negative + ER mutation (0)
HR positive + HER-2 negative + TMB-L (0)
PIK3CA mutation + ER negative + PGR positive (0)
›
Associations
News
Trials
VERI cancer hierarchy
Reset Filters
ER positive
Estrogen Receptor Positive Breast Cancer
ER positive
Estrogen Receptor Positive Breast Cancer
fulvestrant
Sensitive: A1 - Approval
fulvestrant
Sensitive
:
A1
fulvestrant
Sensitive: A1 - Approval
fulvestrant
Sensitive
:
A1
ER positive
Estrogen Receptor Positive Breast Cancer
ER positive
Estrogen Receptor Positive Breast Cancer
exemestane
Sensitive: A1 - Approval
exemestane
Sensitive
:
A1
exemestane
Sensitive: A1 - Approval
exemestane
Sensitive
:
A1
ER positive
Estrogen Receptor Positive Breast Cancer
ER positive
Estrogen Receptor Positive Breast Cancer
toremifene
Sensitive: A1 - Approval
toremifene
Sensitive
:
A1
toremifene
Sensitive: A1 - Approval
toremifene
Sensitive
:
A1
ER positive
Estrogen Receptor Positive Breast Cancer
ER positive
Estrogen Receptor Positive Breast Cancer
goserelin acetate
Sensitive: A1 - Approval
goserelin acetate
Sensitive
:
A1
goserelin acetate
Sensitive: A1 - Approval
goserelin acetate
Sensitive
:
A1
ER positive
HER2 Positive Breast Cancer
ER positive
HER2 Positive Breast Cancer
trastuzumab + lapatinib
Sensitive: A2 - Guideline
trastuzumab + lapatinib
Sensitive
:
A2
trastuzumab + lapatinib
Sensitive: A2 - Guideline
trastuzumab + lapatinib
Sensitive
:
A2
ER positive
HER2 Negative Breast Cancer
ER positive
HER2 Negative Breast Cancer
letrozole
Sensitive: A2 - Guideline
letrozole
Sensitive
:
A2
letrozole
Sensitive: A2 - Guideline
letrozole
Sensitive
:
A2
ER positive
Endometrial Cancer
ER positive
Endometrial Cancer
ribociclib
Sensitive: A2 - Guideline
ribociclib
Sensitive
:
A2
ribociclib
Sensitive: A2 - Guideline
ribociclib
Sensitive
:
A2
ER positive
Uterine Corpus Leiomyosarcoma
ER positive
Uterine Corpus Leiomyosarcoma
Aromatase inhibitor
Sensitive: A2 - Guideline
Aromatase inhibitor
Sensitive
:
A2
Aromatase inhibitor
Sensitive: A2 - Guideline
Aromatase inhibitor
Sensitive
:
A2
ER positive
HER2 Negative Breast Cancer
ER positive
HER2 Negative Breast Cancer
anastrozole
Sensitive: A2 - Guideline
anastrozole
Sensitive
:
A2
anastrozole
Sensitive: A2 - Guideline
anastrozole
Sensitive
:
A2
ER positive
Endometrial Cancer
ER positive
Endometrial Cancer
abemaciclib
Sensitive: A2 - Guideline
abemaciclib
Sensitive
:
A2
abemaciclib
Sensitive: A2 - Guideline
abemaciclib
Sensitive
:
A2
ER positive
Male Breast Cancer
ER positive
Male Breast Cancer
tamoxifen
Sensitive: A2 - Guideline
tamoxifen
Sensitive
:
A2
tamoxifen
Sensitive: A2 - Guideline
tamoxifen
Sensitive
:
A2
ER positive
HER2 Positive Breast Cancer
ER positive
HER2 Positive Breast Cancer
neratinib
Sensitive: A2 - Guideline
neratinib
Sensitive
:
A2
neratinib
Sensitive: A2 - Guideline
neratinib
Sensitive
:
A2
ER positive
HER2 Negative Breast Cancer
ER positive
HER2 Negative Breast Cancer
CDK4 inhibitor + CDK6 inhibitor
Sensitive: A2 - Guideline
CDK4 inhibitor + CDK6 inhibitor
Sensitive
:
A2
CDK4 inhibitor + CDK6 inhibitor
Sensitive: A2 - Guideline
CDK4 inhibitor + CDK6 inhibitor
Sensitive
:
A2
ER positive
Uterine Corpus Leiomyosarcoma
ER positive
Uterine Corpus Leiomyosarcoma
medroxyprogesterone
Sensitive: A2 - Guideline
medroxyprogesterone
Sensitive
:
A2
medroxyprogesterone
Sensitive: A2 - Guideline
medroxyprogesterone
Sensitive
:
A2
ER positive
Uterine Corpus Leiomyosarcoma
ER positive
Uterine Corpus Leiomyosarcoma
megestrol
Sensitive: A2 - Guideline
megestrol
Sensitive
:
A2
megestrol
Sensitive: A2 - Guideline
megestrol
Sensitive
:
A2
ER positive
HER2 Negative Breast Cancer
ER positive
HER2 Negative Breast Cancer
gimeracil/oteracil/tegafur
Sensitive: B - Late Trials
gimeracil / oteracil / tegafur
Sensitive
:
B
gimeracil/oteracil/tegafur
Sensitive: B - Late Trials
gimeracil / oteracil / tegafur
Sensitive
:
B
ER positive
HER2 Negative Breast Cancer
ER positive
HER2 Negative Breast Cancer
palbociclib
Sensitive: B - Late Trials
palbociclib
Sensitive
:
B
palbociclib
Sensitive: B - Late Trials
palbociclib
Sensitive
:
B
ER positive
HER2 Negative Breast Cancer
ER positive
HER2 Negative Breast Cancer
cyclophosphamide + thiotepa
Sensitive: B - Late Trials
cyclophosphamide + thiotepa
Sensitive
:
B
cyclophosphamide + thiotepa
Sensitive: B - Late Trials
cyclophosphamide + thiotepa
Sensitive
:
B
ER positive
HER2 Positive Breast Cancer
ER positive
HER2 Positive Breast Cancer
trastuzumab
Sensitive: B - Late Trials
trastuzumab
Sensitive
:
B
trastuzumab
Sensitive: B - Late Trials
trastuzumab
Sensitive
:
B
ER positive
HER2 Negative Breast Cancer
ER positive
HER2 Negative Breast Cancer
GDC-0032
Sensitive: B - Late Trials
GDC-0032
Sensitive
:
B
GDC-0032
Sensitive: B - Late Trials
GDC-0032
Sensitive
:
B
ER positive
HER2 Negative Breast Cancer
ER positive
HER2 Negative Breast Cancer
ribociclib
Sensitive: B - Late Trials
ribociclib
Sensitive
:
B
ribociclib
Sensitive: B - Late Trials
ribociclib
Sensitive
:
B
ER positive
Estrogen Receptor Positive Breast Cancer
ER positive
Estrogen Receptor Positive Breast Cancer
palbociclib
Sensitive: B - Late Trials
palbociclib
Sensitive
:
B
palbociclib
Sensitive: B - Late Trials
palbociclib
Sensitive
:
B
ER positive
HER2 Negative Breast Cancer
ER positive
HER2 Negative Breast Cancer
ARV-471
Sensitive: B - Late Trials
ARV-471
Sensitive
:
B
ARV-471
Sensitive: B - Late Trials
ARV-471
Sensitive
:
B
ER positive
HER2 Negative Breast Cancer
ER positive
HER2 Negative Breast Cancer
Sensitive: B - Late Trials
Sensitive
:
B
Sensitive: B - Late Trials
Sensitive
:
B
ER positive
HER2 Negative Breast Cancer
ER positive
HER2 Negative Breast Cancer
elacestrant
Sensitive: B - Late Trials
elacestrant
Sensitive
:
B
elacestrant
Sensitive: B - Late Trials
elacestrant
Sensitive
:
B
ER positive
Estrogen Receptor Positive Breast Cancer
ER positive
Estrogen Receptor Positive Breast Cancer
elacestrant
Sensitive: B - Late Trials
elacestrant
Sensitive
:
B
elacestrant
Sensitive: B - Late Trials
elacestrant
Sensitive
:
B
ER positive
HER2 Negative Breast Cancer
ER positive
HER2 Negative Breast Cancer
CFI-402257
Sensitive: B - Late Trials
CFI-402257
Sensitive
:
B
CFI-402257
Sensitive: B - Late Trials
CFI-402257
Sensitive
:
B
ER positive
HER2 Negative Breast Cancer
ER positive
HER2 Negative Breast Cancer
OP-1250
Sensitive: B - Late Trials
OP-1250
Sensitive
:
B
OP-1250
Sensitive: B - Late Trials
OP-1250
Sensitive
:
B
ER positive
HER2 Negative Breast Cancer
ER positive
HER2 Negative Breast Cancer
pembrolizumab
Sensitive: B - Late Trials
pembrolizumab
Sensitive
:
B
pembrolizumab
Sensitive: B - Late Trials
pembrolizumab
Sensitive
:
B
ER positive
HER2 Negative Breast Cancer
ER positive
HER2 Negative Breast Cancer
abemaciclib + eFT226
Sensitive: B - Late Trials
abemaciclib + eFT226
Sensitive
:
B
abemaciclib + eFT226
Sensitive: B - Late Trials
abemaciclib + eFT226
Sensitive
:
B
ER positive
HER2 Negative Breast Cancer
ER positive
HER2 Negative Breast Cancer
exemestane
Sensitive: C1 - Off-label
exemestane
Sensitive
:
C1
exemestane
Sensitive: C1 - Off-label
exemestane
Sensitive
:
C1
ER positive
HER2 Negative Breast Cancer
ER positive
HER2 Negative Breast Cancer
fulvestrant
Sensitive: C1 - Off-label
fulvestrant
Sensitive
:
C1
fulvestrant
Sensitive: C1 - Off-label
fulvestrant
Sensitive
:
C1
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