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BIOMARKER:
EML4-NTRK3 fusion
i
Other names:
NTRK3, TRKC, Neurotrophic tyrosine kinase, receptor, type 3, EML4, EMAP Like 4, Restrictedly Overexpressed Proliferation-Associated Protein, Echinoderm Microtubule-Associated Protein-Like 4, Echinoderm Microtubule Associated Protein Like 4, Ropp 120, C2orf2, EMAP-4, EMAPL4, ROPP120, ELP120
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Entrez ID:
4916
;
27436
Related biomarkers:
Expression
Mutation
Fusion
Others
‹
EML4-ALK variant 3 + TP53 mutation (5)
EML4-ALK fusion + ALK F1174L + ALK S1189C (3)
EML4-ALK fusion + ALK positive (3)
IDH1 mutation + Chr del(1p) + Chr del(19q) + NTRK3 fusion (2)
IDH1 mutation + NTRK3 fusion (2)
IDH2 mutation + Chr del(1p) + Chr del(19q) + NTRK3 fusion (2)
IDH2 mutation + NTRK3 fusion (2)
EML4-ALK + ALK G1202R + LIPI-NTRK1 (2)
EML4-ALK fusion + ALK G1202R (2)
EML4-ALK fusion + ALK rearrangement (2)
EML4-ALK fusion + TP53 mutation (2)
EML4-ALK gene fusion + EGFR exon 19 deletion + EGFR T790M + EGFR C797G (2)
MSI-H/dMMR + NTRK3 fusion (1)
NTRK3 mutation + TMB-H (1)
ALK fusion + EML4-ALK variant 3 + TP53 mutation (1)
ALK positive + EML4-ALK fusion + TP53 mutation (1)
ALK rearrangement + EML4-ALK fusion + CCDC148-ALK fusion + PKDCC-ALK fusion + VIT-ALK fusion (1)
ALK-EML4_V3a + PD-L1 overexpression (1)
ALK-EML4_V3b + PD-L1 overexpression (1)
EML4-ALK fusion + ALK I1171N (1)
EML4-ALK fusion + ALK I1171T (1)
EML4-ALK fusion + NFKBIA amplification + NKX2-1 amplification (1)
EML4-ALK fusion + TMB-L (1)
EML4-ALK fusion v1insLTBP1 (1)
STRN-ALK fusion + EML4-ALK fusion + EGFR T790M (1)
EML4-ALK variant 3 + TP53 mutation (5)
EML4-ALK fusion + ALK F1174L + ALK S1189C (3)
EML4-ALK fusion + ALK positive (3)
IDH1 mutation + Chr del(1p) + Chr del(19q) + NTRK3 fusion (2)
IDH1 mutation + NTRK3 fusion (2)
IDH2 mutation + Chr del(1p) + Chr del(19q) + NTRK3 fusion (2)
IDH2 mutation + NTRK3 fusion (2)
EML4-ALK + ALK G1202R + LIPI-NTRK1 (2)
EML4-ALK fusion + ALK G1202R (2)
EML4-ALK fusion + ALK rearrangement (2)
EML4-ALK fusion + TP53 mutation (2)
EML4-ALK gene fusion + EGFR exon 19 deletion + EGFR T790M + EGFR C797G (2)
MSI-H/dMMR + NTRK3 fusion (1)
NTRK3 mutation + TMB-H (1)
ALK fusion + EML4-ALK variant 3 + TP53 mutation (1)
ALK positive + EML4-ALK fusion + TP53 mutation (1)
ALK rearrangement + EML4-ALK fusion + CCDC148-ALK fusion + PKDCC-ALK fusion + VIT-ALK fusion (1)
ALK-EML4_V3a + PD-L1 overexpression (1)
ALK-EML4_V3b + PD-L1 overexpression (1)
EML4-ALK fusion + ALK I1171N (1)
EML4-ALK fusion + ALK I1171T (1)
EML4-ALK fusion + NFKBIA amplification + NKX2-1 amplification (1)
EML4-ALK fusion + TMB-L (1)
EML4-ALK fusion v1insLTBP1 (1)
STRN-ALK fusion + EML4-ALK fusion + EGFR T790M (1)
›
Associations
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VERI cancer hierarchy
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EML4-NTRK3 fusion
Solid Tumor
EML4-NTRK3 fusion
Solid Tumor
entrectinib
Sensitive: C3 – Early Trials
entrectinib
Sensitive
:
C3
entrectinib
Sensitive: C3 – Early Trials
entrectinib
Sensitive
:
C3
EML4-NTRK3 fusion
Lung Adenocarcinoma
EML4-NTRK3 fusion
Lung Adenocarcinoma
entrectinib
Sensitive: C4 – Case Studies
entrectinib
Sensitive
:
C4
entrectinib
Sensitive: C4 – Case Studies
entrectinib
Sensitive
:
C4
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