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Association details:
Evidence:
Evidence Level:
Sensitive: C3 – Early Trials
New
Source:
Title:

UPDATED ENTRECTINIB DATA FROM A PHASE 1/2 TRIAL IN CHILDREN AND ADOLESCENTS WITH RECURRENT OR REFRACTORY SOLID TUMORS, INCLUDING PRIMARY CENTRAL NERVOUS SYSTEM (CNS) TUMORS

Excerpt:
STARTRK-NG (NCT02650401) is a phase 1/2 trial evaluating the efficacy and safety of entrectinib, a CNS-penetrant TRK/ROS1/ALK tyrosine kinase inhibitor, in pediatric patients with primary brain tumors or extracranial solid tumors. Eight patients had fusion-positive extracranial solid tumors (ORR 8/8; 100%), best responses: 3 CR (DCTN1-ALK, ETV6-NTRK3 [n=2]), 5 PR (EML4-NTRK3, KIF5B-ALK, TFG-ROS1 [n=3]).