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BIOMARKER:

EGFR exon 2-7 deletion + EGFR amplification

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Entrez ID:

Related biomarkers:

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EGFR mutation (196)

EGFR L858R (90)

EGFR T790M (64)

EGFR exon 20 insertion (50)

EGFR wild-type (41)

EGFR L861Q (23)

EGFR C797S (22)

EGFR exon 21 mutation (20)

EGFR L858R + EGFR T790M (16)

EGFR exon 19 mutation (14)

EGFR A763_Y764insFQEA (13)

EGFR G719X (13)

EGFR S768I (12)

EGFR mutation + TP53 mutation (11)

EGFR C797S + EGFR T790M + EGFR L858R (9)

EGFR C797S + EGFR T790M + EGFR exon 19 deletion (9)

EGFR E746_A750del (8)

EGFR exon 20 mutation (8)

EGFRvIII mutation (8)

EGFR exon 18 mutation (7)

EGFR wild-type + ALK wild-type (7)

EGFR T790M + EGFR C797S (6)

EGFR exon 19 deletion + EGFR L861Q (6)

EGFR mutation + BRAF V600E (6)

EGFR G719X + EGFR S768I (5)

EGFR K745_E746insIPVAIK (5)

EGFR L861Q + EGFR G719X (4)

EGFR mutation + KRAS mutation (4)

EGFR mutation + PIK3CA mutation (4)

EGFR D770 delinsGY (3)

EGFR D770_N771insSVD (3)

EGFR E709_T710delinsD (3)

EGFR E746_S752delinsV (3)

EGFR H773_V774insH (3)

EGFR L833V + EGFR H835L (3)

EGFR L858R + EGFR M766Q (3)

EGFR T790M negative (3)

EGFR exon 18-25 duplication (3)

EGFR exon 19 deletion + EGFR C797S (3)

EGFR exon 19 deletion + EGFR T790M + EGFR C797S (3)

EGFR mutation + CREBBP mutation (3)

HER-2 V777L + EGFR L858R (3)

EGFR A767_V769dup (2)

EGFR D770_N771insGT (2)

EGFR G719A + EGFR G779C (2)

EGFR G719C + EGFR S768I (2)

EGFR G719S + EGFR L861Q (2)

EGFR L747-S752 del (2)

EGFR L747_A750delinsP (2)

EGFR L833F + EGFR L861Q (2)

EGFR L858R + EGFR A871G (2)

EGFR L858R + EGFR L718Q (2)

EGFR L858R + RBM10 Y36* (2)

EGFR L858R + TP53 mutation (2)

EGFR N771delinsKG (2)

EGFR S645C + EGFR L858R (2)

EGFR T790M + KRAS mutation (2)

EGFR T790M + PIK3CA H1047R (2)

EGFR V802I + KRAS mutation (2)

EGFR exon 19 duplication (2)

EGFR exon 19 insertion (2)

EGFR exon 20 insertion + EGFR T790M (2)

EGFR mutation + ATM mutation (2)

EGFR mutation + BRAF V600 (2)

EGFR mutation + CDKN2A mutation (2)

EGFR mutation + EGFR T790M (2)

EGFR mutation + MET mutation (2)

EGFR mutation + NRAS Q61K (2)

EGFR mutation + PTEN mutation (2)

EGFR mutation + TP53 mutation + ARID1A mutation (2)

EGFR mutation + TP53 mutation + BRCA1 mutation (2)

EGFR mutation + TP53 mutation + NF1 mutation (2)

EGFR mutation + TP53 mutation + PTEN mutation (2)

EGFR mutation + TP53 mutation + RB1 mutation (2)

EGFR delE709_T710insD (2)

KRAS mutation + EGFR wild-type (2)

MET exon 14 mutation + EGFR exon 20 insertion (2)

ALK L1152R + EGFR mutation (1)

ALK rearrangement + ALK T1151M + ALK L1198F + EGFR A839V (1)

ALK rearrangement + EGFR D761N + KRAS V14I (1)

ALK rearrangement + TP53 R175H + EGFR A839V + PI3KCA mutation (1)

BRAF mutation + EGFR mutation (1)

CDK4 mutation + EGFR mutation (1)

DDR + EGFR mutation (1)

EGFR 181946 C>T (1)

EGFR A767_V769dupASV (1)

EGFR A767dupASV (1)

EGFR C796S + EGFR V802I (1)

EGFR C797S + EGFR C796S (1)

EGFR C797S + EGFR exon 20 insertion (1)

EGFR D770_N771insGL (1)

EGFR D770_N771insGT + EGFR V774_C775insHV (1)

EGFR E709A + EGFR G719C (1)

EGFR E746_T751delinsl (1)

EGFR G2607A (1)

EGFR G719A + EGFR I706T (1)

EGFR G719A + EGFR L833V (1)

EGFR G719A + EGFR R776C (1)

EGFR G719A + EGFR S768I (1)

EGFR G719A + EGFR T790M (1)

EGFR G719C + EGFR E709V (1)

EGFR G719S + EGFR S768I (1)

EGFR G719X + EGFR E709F (1)

EGFR G719X + EGFR L861Q + EGFR S768I (1)

EGFR G719X + TP53 mutation (1)

EGFR G724S + EGFR R776H (1)

EGFR H773L + EGFR V774M (1)

EGFR H773_V774insNPH (1)

EGFR H773delinsNPY (1)

EGFR H773delinsYNPY (1)

EGFR I744_K745insKIPVAI (1)

EGFR L718V + TP53 V727M + EGFR L858R (1)

EGFR L746_T70delinsS (1)

EGFR L746_T750del (1)

EGFR L747_A750>P (1)

EGFR L747_P753delinsS (1)

EGFR L747_T751delinsP (1)

EGFR L747_T751delinsS (1)

EGFR L747_T753delinsS (1)

EGFR L8585R + EGFR T790M + RBM10 G840fs*7 (1)

EGFR L858R + ALK R1275Q (1)

EGFR L858R + ALK rearrangement (1)

EGFR L858R + EGFR C797S (1)

EGFR L858R + EGFR D761Y (1)

EGFR L858R + EGFR E709G (1)

EGFR L858R + EGFR E709X (1)

EGFR L858R + EGFR E709X + CTNNB1 mutation (1)

EGFR L858R + EGFR E884K (1)

EGFR L858R + EGFR L747V (1)

EGFR L858R + EGFR R776H (1)

EGFR L858R + EGFR S765I (1)

EGFR L858R + EGFR S768I (1)

EGFR L858R + EGFR T854A (1)

EGFR L858R + EGFR V843I (1)

EGFR L858R + EGFR exon 21 deletion (1)

EGFR L858R + FGF3 mutation (1)

EGFR L858R + IDH1 R132C (1)

EGFR L858R + PIK3CA H1047R + PIK3CA E545K (1)

EGFR L858R + RBM10 2167-1 G>T (1)

EGFR L858R + RBM10 Q255* (1)

EGFR L858R + RBM10 Q595* (1)

EGFR L858R + TP53 R273C + HER-2 S442L (1)

EGFR L858R + TP53 wild-type (1)

EGFR L861Q + EGFR exon 20 insertion (1)

EGFR L861Q + TP53 mutation (1)

EGFR L861Q + TP53 mutation + RB1 mutation (1)

EGFR M766_A767insASV (1)

EGFR N771_P772insH (1)

EGFR N771_P772insVal (1)

EGFR P772_H773insYNP (1)

EGFR P772_H773insYNP + EGFR H773Y (1)

EGFR P772_V774insPHV (1)

EGFR R1052K (1)

EGFR R776C + EGFR L861Q (1)

EGFR R776H + EGFR C797S (1)

EGFR R776H + EGFR L861Q (1)

EGFR S752_I759del (1)

EGFR S768I + TP53 mutation (1)

EGFR S768_D770dup (1)

EGFR S768_D770dupSVD (1)

EGFR S768dupSVD (1)

EGFR T751_I759>S (1)

EGFR T790M + BRAF V600E (1)

EGFR T790M + EGFR L792F (1)

EGFR T790M + EGFR L833V + EGFR H835L (1)

EGFR T790M + EGFR L861Q (1)

EGFR T790M + EGFR S768I + EGFR L858R (1)

EGFR T790M + HER-2 mutation (1)

EGFR T790M + KRAS G12V (1)

EGFR T790M + MET mutation (1)

EGFR T790M + PARP1 mutation (1)

EGFR T790M + PIK3CA Mutation (1)

EGFR T790M + TP53 R237C (1)

EGFR T854A + EGFR T790M (1)

EGFR V769_770insASV (1)

EGFR V774_C775insHV (1)

EGFR Y764_V765insHH (1)

EGFR exon 18 mutation + EGFR exon 21 mutation (1)

EGFR exon 19 deletion + ALK mutation (1)

EGFR exon 19 deletion + ATM S1455fs*36 + MYC E62K (1)

EGFR exon 19 deletion + BRAF V600E (1)

EGFR exon 19 deletion + BRCA2 mutation (1)

EGFR exon 19 deletion + EGFR G724S + EGFR T790M (1)

EGFR exon 19 deletion + EGFR T790L (1)

EGFR exon 19 deletion + TP53 exon 8 mutation (1)

EGFR exon 19 deletion + TP53 mutation (1)

EGFR exon 19 mutation + EGFR C797S + PIK3CA mutation (1)

EGFR exon 20 insertion + EGFR G719X + EGFR L858R (1)

EGFR exon 20 insertion + NRAS G13V + NF1 R69fs + NF1 S340fs (1)

EGFR exon 20 insertion + TP53 G244A + SPTA1 mutation (1)

EGFR exon 20 mutation + EGFR V774M + EGFR S768I (1)

EGFR exon 21 deletion + EGFR L858R + MET Exon 14 mutation (1)

EGFR exon 21 mutation + EGFR L858R (1)

EGFR mutation + ALK mutation (1)

EGFR mutation + BRAF G469A (1)

EGFR mutation + BRAF mutation + TP53 mutation (1)

EGFR mutation + CTBP2 rs376695472 (1)

EGFR mutation + CTBP2 rs945665113 (1)

EGFR mutation + EGFR T790M + EGFR C797S (1)

EGFR mutation + FAT3 mutation (1)

EGFR mutation + GRM8 mutation (1)

EGFR mutation + HLA-DRB5 rs1071748 (1)

EGFR mutation + HLA-DRB5 rs184278615 (1)

EGFR mutation + HLA-DRB5 rs20146916 (1)

EGFR mutation + IDH1 mutation (1)

EGFR mutation + KIR3DL1 rs199822561 (1)

EGFR mutation + KIR3DL1 rs200821495 (1)

EGFR mutation + KIR3DL1 rs72629105 (1)

EGFR mutation + KIR3DL2 rs973541788 (1)

EGFR mutation + LRP1B mutation (1)

EGFR mutation + MDM4 *32C>A (1)

EGFR mutation + MET Y1003N (1)

EGFR mutation + NOTCH1 mutation (1)

EGFR mutation + RB1 mutation (1)

EGFR mutation + SMAD4 mutation (1)

EGFR mutation + TP53 exon 6 mutation (1)

EGFR mutation + TP53 exon 7 mutation (1)

EGFR mutation + UBXN11 mutation (1)

EGFR mutation + ZNF217 mutation (1)

EGFR mutation+ IDH1 R132H (1)

EGFR rearrangement (1)

EGFR wild-type + ALK wild-type + ROS1 wild-type (1)

EGFR wild-type + ALK wild-type + STK11 mutation (1)

EGFR wild-type + MET wild-type (1)

EGFR-SEPTIN14 rearrangement (1)

EGFR G729A + EGFR L858R (1)

EGFR T790M + TP53 mutation (1)

IDH1 R132C + EGFR L861Q (1)

IDH2 R140W + EGFR L858R (1)

KRAS codon 12 mutation + KRAS codon 13 mutation + EGFR mutation (1)

MTOR L1433S + EGFR L858R + EGFR T790M (1)

EGFR L747_S752del (0)

EGFR L747_T750del (0)

EGFR L858R + EGFR G779S (0)

EGFR L858R + RBM10 Q255 (0)

EGFR T785A + EGFR L861Q + EGFR H297_E298 (0)

EGFR mutation + APC mutation (0)

EGFR rs4947492 (0)

MET exon 14 skipping mutation + EGFR G709T (0)

EGFR mutation (196)

EGFR L858R (90)

EGFR T790M (64)

EGFR exon 20 insertion (50)

EGFR wild-type (41)

EGFR L861Q (23)

EGFR C797S (22)

EGFR exon 21 mutation (20)

EGFR L858R + EGFR T790M (16)

EGFR exon 19 mutation (14)

EGFR A763_Y764insFQEA (13)

EGFR G719X (13)

EGFR S768I (12)

EGFR mutation + TP53 mutation (11)

EGFR C797S + EGFR T790M + EGFR L858R (9)

EGFR C797S + EGFR T790M + EGFR exon 19 deletion (9)

EGFR E746_A750del (8)

EGFR exon 20 mutation (8)

EGFRvIII mutation (8)

EGFR exon 18 mutation (7)

EGFR wild-type + ALK wild-type (7)

EGFR T790M + EGFR C797S (6)

EGFR exon 19 deletion + EGFR L861Q (6)

EGFR mutation + BRAF V600E (6)

EGFR G719X + EGFR S768I (5)

EGFR K745_E746insIPVAIK (5)

EGFR L861Q + EGFR G719X (4)

EGFR mutation + KRAS mutation (4)

EGFR mutation + PIK3CA mutation (4)

EGFR D770 delinsGY (3)

EGFR D770_N771insSVD (3)

EGFR E709_T710delinsD (3)

EGFR E746_S752delinsV (3)

EGFR H773_V774insH (3)

EGFR L833V + EGFR H835L (3)

EGFR L858R + EGFR M766Q (3)

EGFR T790M negative (3)

EGFR exon 18-25 duplication (3)

EGFR exon 19 deletion + EGFR C797S (3)

EGFR exon 19 deletion + EGFR T790M + EGFR C797S (3)

EGFR mutation + CREBBP mutation (3)

HER-2 V777L + EGFR L858R (3)

EGFR A767_V769dup (2)

EGFR D770_N771insGT (2)

EGFR G719A + EGFR G779C (2)

EGFR G719C + EGFR S768I (2)

EGFR G719S + EGFR L861Q (2)

EGFR L747-S752 del (2)

EGFR L747_A750delinsP (2)

EGFR L833F + EGFR L861Q (2)

EGFR L858R + EGFR A871G (2)

EGFR L858R + EGFR L718Q (2)

EGFR L858R + RBM10 Y36* (2)

EGFR L858R + TP53 mutation (2)

EGFR N771delinsKG (2)

EGFR S645C + EGFR L858R (2)

EGFR T790M + KRAS mutation (2)

EGFR T790M + PIK3CA H1047R (2)

EGFR V802I + KRAS mutation (2)

EGFR exon 19 duplication (2)

EGFR exon 19 insertion (2)

EGFR exon 20 insertion + EGFR T790M (2)

EGFR mutation + ATM mutation (2)

EGFR mutation + BRAF V600 (2)

EGFR mutation + CDKN2A mutation (2)

EGFR mutation + EGFR T790M (2)

EGFR mutation + MET mutation (2)

EGFR mutation + NRAS Q61K (2)

EGFR mutation + PTEN mutation (2)

EGFR mutation + TP53 mutation + ARID1A mutation (2)

EGFR mutation + TP53 mutation + BRCA1 mutation (2)

EGFR mutation + TP53 mutation + NF1 mutation (2)

EGFR mutation + TP53 mutation + PTEN mutation (2)

EGFR mutation + TP53 mutation + RB1 mutation (2)

EGFR delE709_T710insD (2)

KRAS mutation + EGFR wild-type (2)

MET exon 14 mutation + EGFR exon 20 insertion (2)

ALK L1152R + EGFR mutation (1)

ALK rearrangement + ALK T1151M + ALK L1198F + EGFR A839V (1)

ALK rearrangement + EGFR D761N + KRAS V14I (1)

ALK rearrangement + TP53 R175H + EGFR A839V + PI3KCA mutation (1)

BRAF mutation + EGFR mutation (1)

CDK4 mutation + EGFR mutation (1)

DDR + EGFR mutation (1)

EGFR 181946 C>T (1)

EGFR A767_V769dupASV (1)

EGFR A767dupASV (1)

EGFR C796S + EGFR V802I (1)

EGFR C797S + EGFR C796S (1)

EGFR C797S + EGFR exon 20 insertion (1)

EGFR D770_N771insGL (1)

EGFR D770_N771insGT + EGFR V774_C775insHV (1)

EGFR E709A + EGFR G719C (1)

EGFR E746_T751delinsl (1)

EGFR G2607A (1)

EGFR G719A + EGFR I706T (1)

EGFR G719A + EGFR L833V (1)

EGFR G719A + EGFR R776C (1)

EGFR G719A + EGFR S768I (1)

EGFR G719A + EGFR T790M (1)

EGFR G719C + EGFR E709V (1)

EGFR G719S + EGFR S768I (1)

EGFR G719X + EGFR E709F (1)

EGFR G719X + EGFR L861Q + EGFR S768I (1)

EGFR G719X + TP53 mutation (1)

EGFR G724S + EGFR R776H (1)

EGFR H773L + EGFR V774M (1)

EGFR H773_V774insNPH (1)

EGFR H773delinsNPY (1)

EGFR H773delinsYNPY (1)

EGFR I744_K745insKIPVAI (1)

EGFR L718V + TP53 V727M + EGFR L858R (1)

EGFR L746_T70delinsS (1)

EGFR L746_T750del (1)

EGFR L747_A750>P (1)

EGFR L747_P753delinsS (1)

EGFR L747_T751delinsP (1)

EGFR L747_T751delinsS (1)

EGFR L747_T753delinsS (1)

EGFR L8585R + EGFR T790M + RBM10 G840fs*7 (1)

EGFR L858R + ALK R1275Q (1)

EGFR L858R + ALK rearrangement (1)

EGFR L858R + EGFR C797S (1)

EGFR L858R + EGFR D761Y (1)

EGFR L858R + EGFR E709G (1)

EGFR L858R + EGFR E709X (1)

EGFR L858R + EGFR E709X + CTNNB1 mutation (1)

EGFR L858R + EGFR E884K (1)

EGFR L858R + EGFR L747V (1)

EGFR L858R + EGFR R776H (1)

EGFR L858R + EGFR S765I (1)

EGFR L858R + EGFR S768I (1)

EGFR L858R + EGFR T854A (1)

EGFR L858R + EGFR V843I (1)

EGFR L858R + EGFR exon 21 deletion (1)

EGFR L858R + FGF3 mutation (1)

EGFR L858R + IDH1 R132C (1)

EGFR L858R + PIK3CA H1047R + PIK3CA E545K (1)

EGFR L858R + RBM10 2167-1 G>T (1)

EGFR L858R + RBM10 Q255* (1)

EGFR L858R + RBM10 Q595* (1)

EGFR L858R + TP53 R273C + HER-2 S442L (1)

EGFR L858R + TP53 wild-type (1)

EGFR L861Q + EGFR exon 20 insertion (1)

EGFR L861Q + TP53 mutation (1)

EGFR L861Q + TP53 mutation + RB1 mutation (1)

EGFR M766_A767insASV (1)

EGFR N771_P772insH (1)

EGFR N771_P772insVal (1)

EGFR P772_H773insYNP (1)

EGFR P772_H773insYNP + EGFR H773Y (1)

EGFR P772_V774insPHV (1)

EGFR R1052K (1)

EGFR R776C + EGFR L861Q (1)

EGFR R776H + EGFR C797S (1)

EGFR R776H + EGFR L861Q (1)

EGFR S752_I759del (1)

EGFR S768I + TP53 mutation (1)

EGFR S768_D770dup (1)

EGFR S768_D770dupSVD (1)

EGFR S768dupSVD (1)

EGFR T751_I759>S (1)

EGFR T790M + BRAF V600E (1)

EGFR T790M + EGFR L792F (1)

EGFR T790M + EGFR L833V + EGFR H835L (1)

EGFR T790M + EGFR L861Q (1)

EGFR T790M + EGFR S768I + EGFR L858R (1)

EGFR T790M + HER-2 mutation (1)

EGFR T790M + KRAS G12V (1)

EGFR T790M + MET mutation (1)

EGFR T790M + PARP1 mutation (1)

EGFR T790M + PIK3CA Mutation (1)

EGFR T790M + TP53 R237C (1)

EGFR T854A + EGFR T790M (1)

EGFR V769_770insASV (1)

EGFR V774_C775insHV (1)

EGFR Y764_V765insHH (1)

EGFR exon 18 mutation + EGFR exon 21 mutation (1)

EGFR exon 19 deletion + ALK mutation (1)

EGFR exon 19 deletion + ATM S1455fs*36 + MYC E62K (1)

EGFR exon 19 deletion + BRAF V600E (1)

EGFR exon 19 deletion + BRCA2 mutation (1)

EGFR exon 19 deletion + EGFR G724S + EGFR T790M (1)

EGFR exon 19 deletion + EGFR T790L (1)

EGFR exon 19 deletion + TP53 exon 8 mutation (1)

EGFR exon 19 deletion + TP53 mutation (1)

EGFR exon 19 mutation + EGFR C797S + PIK3CA mutation (1)

EGFR exon 20 insertion + EGFR G719X + EGFR L858R (1)

EGFR exon 20 insertion + NRAS G13V + NF1 R69fs + NF1 S340fs (1)

EGFR exon 20 insertion + TP53 G244A + SPTA1 mutation (1)

EGFR exon 20 mutation + EGFR V774M + EGFR S768I (1)

EGFR exon 21 deletion + EGFR L858R + MET Exon 14 mutation (1)

EGFR exon 21 mutation + EGFR L858R (1)

EGFR mutation + ALK mutation (1)

EGFR mutation + BRAF G469A (1)

EGFR mutation + BRAF mutation + TP53 mutation (1)

EGFR mutation + CTBP2 rs376695472 (1)

EGFR mutation + CTBP2 rs945665113 (1)

EGFR mutation + EGFR T790M + EGFR C797S (1)

EGFR mutation + FAT3 mutation (1)

EGFR mutation + GRM8 mutation (1)

EGFR mutation + HLA-DRB5 rs1071748 (1)

EGFR mutation + HLA-DRB5 rs184278615 (1)

EGFR mutation + HLA-DRB5 rs20146916 (1)

EGFR mutation + IDH1 mutation (1)

EGFR mutation + KIR3DL1 rs199822561 (1)

EGFR mutation + KIR3DL1 rs200821495 (1)

EGFR mutation + KIR3DL1 rs72629105 (1)

EGFR mutation + KIR3DL2 rs973541788 (1)

EGFR mutation + LRP1B mutation (1)

EGFR mutation + MDM4 *32C>A (1)

EGFR mutation + MET Y1003N (1)

EGFR mutation + NOTCH1 mutation (1)

EGFR mutation + RB1 mutation (1)

EGFR mutation + SMAD4 mutation (1)

EGFR mutation + TP53 exon 6 mutation (1)

EGFR mutation + TP53 exon 7 mutation (1)

EGFR mutation + UBXN11 mutation (1)

EGFR mutation + ZNF217 mutation (1)

EGFR mutation+ IDH1 R132H (1)

EGFR rearrangement (1)

EGFR wild-type + ALK wild-type + ROS1 wild-type (1)

EGFR wild-type + ALK wild-type + STK11 mutation (1)

EGFR wild-type + MET wild-type (1)

EGFR-SEPTIN14 rearrangement (1)

EGFR G729A + EGFR L858R (1)

EGFR T790M + TP53 mutation (1)

IDH1 R132C + EGFR L861Q (1)

IDH2 R140W + EGFR L858R (1)

KRAS codon 12 mutation + KRAS codon 13 mutation + EGFR mutation (1)

MTOR L1433S + EGFR L858R + EGFR T790M (1)

EGFR L747_S752del (0)

EGFR L747_T750del (0)

EGFR L858R + EGFR G779S (0)

EGFR L858R + RBM10 Q255 (0)

EGFR T785A + EGFR L861Q + EGFR H297_E298 (0)

EGFR mutation + APC mutation (0)

EGFR rs4947492 (0)

MET exon 14 skipping mutation + EGFR G709T (0)

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EGFR exon 2-7 deletion + EGFR amplification	Non Small Cell Lung Cancer	EGFR exon 2-7 deletion + EGFR amplification	Non Small Cell Lung Cancer	EGFR inhibitor Resistant: C3 – Early Trials EGFR inhibitor Resistant : C3	EGFR inhibitor Resistant: C3 – Early Trials EGFR inhibitor Resistant : C3
EGFR exon 2-7 deletion + EGFR amplification	Glioblastoma	EGFR exon 2-7 deletion + EGFR amplification	Glioblastoma	bevacizumab + osimertinib Sensitive: C3 – Early Trials bevacizumab + osimertinib Sensitive : C3	bevacizumab + osimertinib Sensitive: C3 – Early Trials bevacizumab + osimertinib Sensitive : C3