^
Association details:
Evidence:
Evidence Level:
Sensitive: C2 – Inclusion Criteria
Title:

Afatinib in Previously Treated ESCC With EGFR Overexpression or EGFR Amplification (ESCC-A01)

Excerpt:
...Immunohistochemistry confirmed EGFR(3+) or EGFR-FISH-amplification or next generation sequencing confirmed EGFR-amplification....
Trial ID:
Evidence Level:
Sensitive: D – Preclinical
Source:
Title:

Phase 2 study of afatinib among patients with recurrent and/or metastatic esophageal squamous cell carcinoma

Published date:
08/04/2020
Excerpt:
As a predictive marker, a score derived from...EGFR amplifications and/or missense mutations demonstrated a significant association with the response to afatinib. The score based on the mutational status of EGFR...achieved a performance of an area under the curve of 0.86 in predicting the sensitivity of afatinib.
DOI:
10.1002/cncr.33123