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Association details:
| Biomarker: | FGFR1 overexpression |
|---|---|
| Cancer: | Bladder Cancer |
| Drug: | dovitinib (TKI258) (FGFR inhibitor, VEGFR inhibitor, PDGFR inhibitor, pan-TRK inhibitor) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
Small molecule FGF receptor inhibitors block FGFR-dependent urothelial carcinoma growth in vitro and in vivo
Excerpt:
One of the responsive cell lines, JMSU1, which does not express FGFR3, overexpresses FGFR1…We showed that the cell line JMSU1 that expresses high levels of FGFR1 was sensitive to treatment.
DOI:
10.1038/sj.bjc.6606016
