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BIOMARKER:
BRCA1 mutation + TMB-H
i
Other names:
TMB | Tumor Mutational Burden, BRCA1, BRCC1, PPP1R53, RNF53, Breast cancer 1, early onset
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Entrez ID:
672
Related biomarkers:
Expression
Mutation
CNA
Fusion
Others
‹
BRCA1 mutation (196)
BRCA wild-type (19)
BRCA1 2110_2111delAA + BRCA1 4071_4096 +14del40 + TP53 R342P + NOTCH2 Q1310H (7)
BRCA1 mutation + BRCA2 mutation (4)
BRCA1 L1780P (2)
BRCA1 R1443* (2)
BRCA1 mutation + TP53 mutation (2)
EGFR mutation + TP53 mutation + BRCA1 mutation (2)
BRCA1 2080delA (1)
BRCA1 307 T> A (L63*) (1)
BRCA1 3363delGAAA (1)
BRCA1 5396insC (1)
BRCA1 E1446* (1)
BRCA1 N1018fs*8 (1)
BRCA1 Q858 (1)
BRCA1 S451Lfs*20 (1)
BRCA1 biallelic inactivation (1)
BRCA1 mutation + ATM mutation (1)
BRCA1 mutation + TP53 R248Q (1)
BRCA1 rearrangement (1)
MSH2 mutation + MSH6 mutation + BRCA1 mutation (1)
BRCA1 mutation (196)
BRCA wild-type (19)
BRCA1 2110_2111delAA + BRCA1 4071_4096 +14del40 + TP53 R342P + NOTCH2 Q1310H (7)
BRCA1 mutation + BRCA2 mutation (4)
BRCA1 L1780P (2)
BRCA1 R1443* (2)
BRCA1 mutation + TP53 mutation (2)
EGFR mutation + TP53 mutation + BRCA1 mutation (2)
BRCA1 2080delA (1)
BRCA1 307 T> A (L63*) (1)
BRCA1 3363delGAAA (1)
BRCA1 5396insC (1)
BRCA1 E1446* (1)
BRCA1 N1018fs*8 (1)
BRCA1 Q858 (1)
BRCA1 S451Lfs*20 (1)
BRCA1 biallelic inactivation (1)
BRCA1 mutation + ATM mutation (1)
BRCA1 mutation + TP53 R248Q (1)
BRCA1 rearrangement (1)
MSH2 mutation + MSH6 mutation + BRCA1 mutation (1)
›
Associations
News
Trials
VERI cancer hierarchy
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BRCA1 mutation + TMB-H
Non Small Cell Lung Cancer
BRCA1 mutation + TMB-H
Non Small Cell Lung Cancer
Immunotherapy
Resistant: C3 – Early Trials
Immunotherapy
Resistant
:
C3
Immunotherapy
Resistant: C3 – Early Trials
Immunotherapy
Resistant
:
C3
BRCA1 mutation + TMB-H
Pancreatic Adenocarcinoma
BRCA1 mutation + TMB-H
Pancreatic Adenocarcinoma
pembrolizumab + olaparib
Sensitive: C4 – Case Studies
pembrolizumab + olaparib
Sensitive
:
C4
pembrolizumab + olaparib
Sensitive: C4 – Case Studies
pembrolizumab + olaparib
Sensitive
:
C4
BRCA1 mutation + TMB-H
Pancreatic Ductal Adenocarcinoma
BRCA1 mutation + TMB-H
Pancreatic Ductal Adenocarcinoma
pembrolizumab + olaparib
Sensitive: C4 – Case Studies
pembrolizumab + olaparib
Sensitive
:
C4
pembrolizumab + olaparib
Sensitive: C4 – Case Studies
pembrolizumab + olaparib
Sensitive
:
C4
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