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BIOMARKER:
BRCA wild-type
i
Other names:
BRCA1, BRCC1, PPP1R53, RNF53, Breast cancer 1, early onset, BRCA2, BRCC2, FACD, FAD, FAD1, FANCD, FANCD1, Breast cancer 2, early onset
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Entrez ID:
672
;
675
Related biomarkers:
Expression
Mutation
CNA
Fusion
Others
‹
BRCA1 expression (3)
BRCA1 positive (2)
BRCA1 underexpression (2)
BRCA2 overexpression (2)
BRCA1 negative (1)
BRCA2 expression (1)
BRCA2 positive (1)
BRCA2 underexpression (1)
BRCA1 expression (3)
BRCA1 positive (2)
BRCA1 underexpression (2)
BRCA2 overexpression (2)
BRCA1 negative (1)
BRCA2 expression (1)
BRCA2 positive (1)
BRCA2 underexpression (1)
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Associations
News
Trials
VERI cancer hierarchy
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BRCA wild-type
Ovarian Cancer
BRCA wild-type
Ovarian Cancer
rucaparib
Sensitive: A2 - Guideline
rucaparib
Sensitive
:
A2
rucaparib
Sensitive: A2 - Guideline
rucaparib
Sensitive
:
A2
BRCA wild-type
Ovarian Cancer
BRCA wild-type
Ovarian Cancer
ABT-888
Sensitive: B - Late Trials
ABT-888
Sensitive
:
B
ABT-888
Sensitive: B - Late Trials
ABT-888
Sensitive
:
B
BRCA wild-type
Ovarian Cancer
BRCA wild-type
Ovarian Cancer
bevacizumab + olaparib + durvalumab
Sensitive: B - Late Trials
bevacizumab + olaparib + durvalumab
Sensitive
:
B
bevacizumab + olaparib + durvalumab
Sensitive: B - Late Trials
bevacizumab + olaparib + durvalumab
Sensitive
:
B
BRCA wild-type
Ovarian Cancer
BRCA wild-type
Ovarian Cancer
AZD1775
Sensitive: C2 – Inclusion Criteria
AZD1775
Sensitive
:
C2
AZD1775
Sensitive: C2 – Inclusion Criteria
AZD1775
Sensitive
:
C2
BRCA wild-type
Triple Negative Breast Cancer
BRCA wild-type
Triple Negative Breast Cancer
olaparib + alpelisib
Sensitive: C3 – Early Trials
olaparib + alpelisib
Sensitive
:
C3
olaparib + alpelisib
Sensitive: C3 – Early Trials
olaparib + alpelisib
Sensitive
:
C3
BRCA wild-type
Breast Cancer
BRCA wild-type
Breast Cancer
talazoparib
Sensitive: C3 – Early Trials
talazoparib
Sensitive
:
C3
talazoparib
Sensitive: C3 – Early Trials
talazoparib
Sensitive
:
C3
BRCA wild-type
Triple Negative Breast Cancer
BRCA wild-type
Triple Negative Breast Cancer
ACR-368
Sensitive: C3 – Early Trials
ACR-368
Sensitive
:
C3
ACR-368
Sensitive: C3 – Early Trials
ACR-368
Sensitive
:
C3
BRCA wild-type
Ovarian Cancer
BRCA wild-type
Ovarian Cancer
pembrolizumab + bevacizumab + olaparib
Sensitive: C3 – Early Trials
pembrolizumab + bevacizumab + olaparib
Sensitive
:
C3
pembrolizumab + bevacizumab + olaparib
Sensitive: C3 – Early Trials
pembrolizumab + bevacizumab + olaparib
Sensitive
:
C3
BRCA wild-type
Triple Negative Breast Cancer
BRCA wild-type
Triple Negative Breast Cancer
talazoparib + ZEN-3694
Sensitive: C3 – Early Trials
talazoparib + ZEN-3694
Sensitive
:
C3
talazoparib + ZEN-3694
Sensitive: C3 – Early Trials
talazoparib + ZEN-3694
Sensitive
:
C3
BRCA wild-type
Ovarian Cancer
BRCA wild-type
Ovarian Cancer
bortezomib
Sensitive: C3 – Early Trials
bortezomib
Sensitive
:
C3
bortezomib
Sensitive: C3 – Early Trials
bortezomib
Sensitive
:
C3
BRCA wild-type
Ovarian Cancer
BRCA wild-type
Ovarian Cancer
carboplatin + paclitaxel
Sensitive: C3 – Early Trials
carboplatin + paclitaxel
Sensitive
:
C3
carboplatin + paclitaxel
Sensitive: C3 – Early Trials
carboplatin + paclitaxel
Sensitive
:
C3
BRCA wild-type
Ovarian Cancer
BRCA wild-type
Ovarian Cancer
bevacizumab + olaparib + atezolizumab
Sensitive: C3 – Early Trials
bevacizumab + olaparib + atezolizumab
Sensitive
:
C3
bevacizumab + olaparib + atezolizumab
Sensitive: C3 – Early Trials
bevacizumab + olaparib + atezolizumab
Sensitive
:
C3
BRCA wild-type
Triple Negative Breast Cancer
BRCA wild-type
Triple Negative Breast Cancer
carboplatin + paclitaxel + cyclophosphamide
Sensitive: C3 – Early Trials
carboplatin + paclitaxel + cyclophosphamide
Sensitive
:
C3
carboplatin + paclitaxel + cyclophosphamide
Sensitive: C3 – Early Trials
carboplatin + paclitaxel + cyclophosphamide
Sensitive
:
C3
BRCA wild-type
HER2 Negative Breast Cancer
BRCA wild-type
HER2 Negative Breast Cancer
DAN-222
Sensitive: C3 – Early Trials
DAN-222
Sensitive
:
C3
DAN-222
Sensitive: C3 – Early Trials
DAN-222
Sensitive
:
C3
BRCA wild-type
HER2 Negative Breast Cancer
BRCA wild-type
HER2 Negative Breast Cancer
niraparib + DAN-222
Sensitive: C3 – Early Trials
niraparib + DAN-222
Sensitive
:
C3
niraparib + DAN-222
Sensitive: C3 – Early Trials
niraparib + DAN-222
Sensitive
:
C3
BRCA wild-type
Triple Negative Breast Cancer
BRCA wild-type
Triple Negative Breast Cancer
MLN4924
Sensitive: D – Preclinical
MLN4924
Sensitive
:
D
MLN4924
Sensitive: D – Preclinical
MLN4924
Sensitive
:
D
BRCA wild-type
Ovarian Cancer
BRCA wild-type
Ovarian Cancer
olaparib + ART12
Sensitive: D – Preclinical
olaparib + ART12
Sensitive
:
D
olaparib + ART12
Sensitive: D – Preclinical
olaparib + ART12
Sensitive
:
D
BRCA wild-type
Ovarian Cancer
BRCA wild-type
Ovarian Cancer
olaparib + cediranib + 3-AP
Sensitive: D – Preclinical
olaparib + cediranib + 3-AP
Sensitive
:
D
olaparib + cediranib + 3-AP
Sensitive: D – Preclinical
olaparib + cediranib + 3-AP
Sensitive
:
D
BRCA wild-type
Triple Negative Breast Cancer
BRCA wild-type
Triple Negative Breast Cancer
olaparib + AZD1775
Sensitive: D – Preclinical
olaparib + AZD1775
Sensitive
:
D
olaparib + AZD1775
Sensitive: D – Preclinical
olaparib + AZD1775
Sensitive
:
D
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