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Association details:
| Biomarker: | BRCA wild-type |
|---|---|
| Cancer: | Ovarian Cancer |
| Drug: | carboplatin (Tubulin polymerization promoter) + paclitaxel (Bcl2 inhibitor, Tubulin polymerization promoter) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
Utility of Adjusting Chemotherapy Dose & Dosing Schedule with the SALVage Weekly Dose-dense Regimen in Patients with Poor Prognostic OVARian Cancers Based on the Tumor Unfavorable Primary Chemosensitivity and Incomplete Debulking Surgery
Excerpt:
...Quality of life questionnaires`Perceptions of the patient-doctor relationship in patients offered bevacizumab/debulking surgery/PARPi`Satisfaction with decision-making process in patients offered bevacizumab/debulking surgery/PARPi`Emotional wellbeing following the decision-making process in patients offered bevacizumab/debulking surgery/PARPi`Treatment beliefs in patients offered bevacizumab/PARPi`Self-reported adherence to PARPi in patients offered PARPi`Percentage of patients with BRCA (BReast CAncer) mutation (%)`Percentage of patients with BRCA wild-type HRD (Homologous Recombination Deficiency) disease (%)`Percentage of patients with BRCA wild-type HRP (Homologous Recombination Proficient) disease (%)`Tests/assays used (names, proprietary)`Percentage of tests/assays used (names, proprietary) (%)`Incremental cost-utility ratio`Incremental cost-effectiveness ratio`Estimate the net financial impact over 5 years...
Trial ID:
Source:
Title:
Efficacy of chemotherapy according to BRCA status in patients with high-grade serous ovarian carcinoma at first platinum-sensitive relapse
Published date:
01/11/2023
Excerpt:
In BRCA wild type patients without maintenance, better progression-free survival occurred with carboplatin/paclitaxel (median progression-free survival 14.3 months) than with carboplatin/gemcitabine and carboplatin/pegylated liposomal doxorubicin (9.8 and 11.8 months, respectively; p=0.017)...treatment with carboplatin/paclitaxel appears to be more effective than carboplatin/gemcitabine and carboplatin/pegylated liposomal doxorubicin in BRCA wild type patients with high-grade serous ovarian cancers at first platinum-sensitive relapse.
DOI:
10.1136/ijgc-2022-003993
