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Association details:
| Biomarker: | TGFB1 elevation |
|---|---|
| Cancer: | Gastroesophageal Cancer |
| Drug: | bintrafusp alfa (M7824) (PD-L1 inhibitor, TGFβ inhibitor) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
Safety and Tolerability of Bintrafusp Alfa, a Bifunctional Fusion Protein Targeting TGFß and PD-L1, in Asian Patients with Pretreated Recurrent or Refractory Gastric Cancer
Published date:
05/27/2020
Excerpt:
Responses occurred irrespective of PD-L1 expression or microsatellite instability status and appeared to correlate with high tumor TGFB1 levels…. In this first evaluation in Asian patients with heavily pretreated advanced GC/GEJC, bintrafusp alfa demonstrated a manageable safety profile and clinical activity.
DOI:
10.1158/1078-0432.CCR-19-3806
