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BIOMARKER:
BCR-ABL1 L248V
i
Other names:
BCR, BCR Activator Of RhoGEF And GTPase, BCR, RhoGEF And GTPase Activating Protein, Breakpoint Cluster Region Protein, Renal Carcinoma Antigen NY-REN-26, Breakpoint Cluster Region, D22S11, BCR1, BCR/FGFR1 Chimera Protein, FGFR1/BCR Chimera Protein, D22S662, ALL, CML, PHL, ABL proto-oncogene 1, ABL, c-ABL, JTK7, p150, ABL1
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Entrez ID:
25
;
613
Related biomarkers:
Expression
Mutation
CNA
Fusion
Others
‹
BCR-ABL1 fusion (70)
BCR-ABL1 T315I (32)
BCR-ABL1 E255K (10)
BCR-ABL1 V299L (10)
BCR-ABL1 F317L (8)
BCR-ABL1 Y253H (8)
BCR-ABL1 E255V (6)
BCR-ABL1 F359C (6)
BCR-ABL1 G250E (6)
BCR-ABL1 M244V (6)
BCR-ABL1 D276G (5)
BCR-ABL1 F359V (5)
BCR-ABL1 M351T (5)
BCR-ABL1 E279K (4)
BCR-ABL1 G398R (4)
BCR-ABL1 H396P (4)
BCR-ABL1 H396R (4)
BCR-ABL1 L384M (4)
BCR-ABL1 Q252H (4)
BCR-ABL1 V379I (4)
BCR-ABL1 Y253F (4)
SNX2-ABL1 fusion (4)
BCR-ABL1 F317V (3)
BCR-ABL1 F359I (3)
BCR-ABL1 F486S (3)
BCR-ABL1 mutation (3)
NUP214-ABL1 fusion (3)
BCR-ABL1 A397P (2)
BCR-ABL1 E355G (2)
BCR-ABL1 E459K (2)
BCR-ABL1 F317C (2)
BCR-ABL1 F317I (2)
BCR-ABL1 L387M (2)
BCR-ABL1 T315A (2)
BCR-FGFR1 fusion (2)
ABL1 fusion (1)
BCR exon 13-ABL1 exon 3 fusion (1)
BCR-ABL1 C475V (1)
BCR-ABL1 D363G (1)
BCR-ABL1 D444G (1)
BCR-ABL1 E292V (1)
BCR-ABL1 E355G + BCR-ABL1 Q252R (1)
BCR-ABL1 E450G (1)
BCR-ABL1 E450Q (1)
BCR-ABL1 E453A (1)
BCR-ABL1 E98G (1)
BCR-ABL1 F311I (1)
BCR-ABL1 F311V (1)
BCR-ABL1 F359 (1)
BCR-ABL1 F3llL (1)
BCR-ABL1 G250E + BCR-ABL1 F317L (1)
BCR-ABL1 I403T (1)
BCR-ABL1 I403V (1)
BCR-ABL1 I432T (1)
BCR-ABL1 L248R (1)
BCR-ABL1 L323P (1)
BCR-ABL1 L364I (1)
BCR-ABL1 L387F (1)
BCR-ABL1 M388L (1)
BCR-ABL1 M388L + BCR-ABL1 M244V (1)
BCR-ABL1 N336S (1)
BCR-ABL1 N49S (1)
BCR-ABL1 Q252R (1)
BCR-ABL1 Q255K (1)
BCR-ABL1 Q300R (1)
BCR-ABL1 S417T (1)
BCR-ABL1 S417Y (1)
BCR-ABL1 T315M (1)
BCR-ABL1 V229L (1)
BCR-ABL1 V289A (1)
BCR-ABL1 V289I (1)
Chr t(3;9)(p13;q34) FOXP1/ABL1 (1)
ETV6-ABL1 fusion (1)
FOXP1-ABL1 Fusion (1)
INPP5D-ABL1 fusion (1)
BCR exon 1-PDGFRA exon 13 fusion (1)
BCR-JAK2 fusion (1)
ABL1-RCSD1 fusion (0)
BCR-ABL1 V289I + BCR-ABL1 M388L (0)
BCR-ABL1 V338G (0)
BCR-ABL1 fusion negative (0)
JAK2-ABL1 fusion (0)
BCR-ABL1 fusion (70)
BCR-ABL1 T315I (32)
BCR-ABL1 E255K (10)
BCR-ABL1 V299L (10)
BCR-ABL1 F317L (8)
BCR-ABL1 Y253H (8)
BCR-ABL1 E255V (6)
BCR-ABL1 F359C (6)
BCR-ABL1 G250E (6)
BCR-ABL1 M244V (6)
BCR-ABL1 D276G (5)
BCR-ABL1 F359V (5)
BCR-ABL1 M351T (5)
BCR-ABL1 E279K (4)
BCR-ABL1 G398R (4)
BCR-ABL1 H396P (4)
BCR-ABL1 H396R (4)
BCR-ABL1 L384M (4)
BCR-ABL1 Q252H (4)
BCR-ABL1 V379I (4)
BCR-ABL1 Y253F (4)
SNX2-ABL1 fusion (4)
BCR-ABL1 F317V (3)
BCR-ABL1 F359I (3)
BCR-ABL1 F486S (3)
BCR-ABL1 mutation (3)
NUP214-ABL1 fusion (3)
BCR-ABL1 A397P (2)
BCR-ABL1 E355G (2)
BCR-ABL1 E459K (2)
BCR-ABL1 F317C (2)
BCR-ABL1 F317I (2)
BCR-ABL1 L387M (2)
BCR-ABL1 T315A (2)
BCR-FGFR1 fusion (2)
ABL1 fusion (1)
BCR exon 13-ABL1 exon 3 fusion (1)
BCR-ABL1 C475V (1)
BCR-ABL1 D363G (1)
BCR-ABL1 D444G (1)
BCR-ABL1 E292V (1)
BCR-ABL1 E355G + BCR-ABL1 Q252R (1)
BCR-ABL1 E450G (1)
BCR-ABL1 E450Q (1)
BCR-ABL1 E453A (1)
BCR-ABL1 E98G (1)
BCR-ABL1 F311I (1)
BCR-ABL1 F311V (1)
BCR-ABL1 F359 (1)
BCR-ABL1 F3llL (1)
BCR-ABL1 G250E + BCR-ABL1 F317L (1)
BCR-ABL1 I403T (1)
BCR-ABL1 I403V (1)
BCR-ABL1 I432T (1)
BCR-ABL1 L248R (1)
BCR-ABL1 L323P (1)
BCR-ABL1 L364I (1)
BCR-ABL1 L387F (1)
BCR-ABL1 M388L (1)
BCR-ABL1 M388L + BCR-ABL1 M244V (1)
BCR-ABL1 N336S (1)
BCR-ABL1 N49S (1)
BCR-ABL1 Q252R (1)
BCR-ABL1 Q255K (1)
BCR-ABL1 Q300R (1)
BCR-ABL1 S417T (1)
BCR-ABL1 S417Y (1)
BCR-ABL1 T315M (1)
BCR-ABL1 V229L (1)
BCR-ABL1 V289A (1)
BCR-ABL1 V289I (1)
Chr t(3;9)(p13;q34) FOXP1/ABL1 (1)
ETV6-ABL1 fusion (1)
FOXP1-ABL1 Fusion (1)
INPP5D-ABL1 fusion (1)
BCR exon 1-PDGFRA exon 13 fusion (1)
BCR-JAK2 fusion (1)
ABL1-RCSD1 fusion (0)
BCR-ABL1 V289I + BCR-ABL1 M388L (0)
BCR-ABL1 V338G (0)
BCR-ABL1 fusion negative (0)
JAK2-ABL1 fusion (0)
›
Associations
News
Trials
VERI cancer hierarchy
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BCR-ABL1 L248V
Chronic Myeloid Leukemia
BCR-ABL1 L248V
Chronic Myeloid Leukemia
dasatinib
Sensitive: B - Late Trials
dasatinib
Sensitive
:
B
dasatinib
Sensitive: B - Late Trials
dasatinib
Sensitive
:
B
BCR-ABL1 L248V
Chronic Myeloid Leukemia
BCR-ABL1 L248V
Chronic Myeloid Leukemia
imatinib
Resistant: C3 – Early Trials
imatinib
Resistant
:
C3
imatinib
Resistant: C3 – Early Trials
imatinib
Resistant
:
C3
BCR-ABL1 L248V
Chronic Myeloid Leukemia
BCR-ABL1 L248V
Chronic Myeloid Leukemia
bosutinib
Sensitive: C3 – Early Trials
bosutinib
Sensitive
:
C3
bosutinib
Sensitive: C3 – Early Trials
bosutinib
Sensitive
:
C3
BCR-ABL1 L248V
Chronic Myeloid Leukemia
BCR-ABL1 L248V
Chronic Myeloid Leukemia
dasatinib + imatinib + nilotinib
Resistant: D – Preclinical
dasatinib + imatinib + nilotinib
Resistant
:
D
dasatinib + imatinib + nilotinib
Resistant: D – Preclinical
dasatinib + imatinib + nilotinib
Resistant
:
D
BCR-ABL1 L248V
Chronic Myeloid Leukemia
BCR-ABL1 L248V
Chronic Myeloid Leukemia
nilotinib
Sensitive: D – Preclinical
nilotinib
Sensitive
:
D
nilotinib
Sensitive: D – Preclinical
nilotinib
Sensitive
:
D
^
^
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