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BIOMARKER:

BCR-ABL1 E255K

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Other names: BCR, BCR Activator Of RhoGEF And GTPase, BCR, RhoGEF And GTPase Activating Protein, Breakpoint Cluster Region Protein, Renal Carcinoma Antigen NY-REN-26, Breakpoint Cluster Region, D22S11, BCR1, BCR/FGFR1 Chimera Protein, FGFR1/BCR Chimera Protein, D22S662, ALL, CML, PHL, ABL proto-oncogene 1, ABL, c-ABL, JTK7, p150, ABL1
Entrez ID:
BCR-ABL1 E255K
CML
nilotinib
Resistant: A2 - Guideline
BCR-ABL1 E255K
ALL
nilotinib
Resistant: A2 - Guideline
BCR-ABL1 E255K
CML
dasatinib
Sensitive: B - Late Trials
BCR-ABL1 E255K
ALL
dasatinib + blinatumomab
Sensitive: C3 – Early Trials
BCR-ABL1 E255K
CML
bosutinib
Resistant: C3 – Early Trials
BCR-ABL1 E255K
CML
imatinib
Resistant: C3 – Early Trials
BCR-ABL1 E255K
ALL
ponatinib
Resistant: C3 – Early Trials
BCR-ABL1 E255K
B Acute Lymphoblastic Leukemia
S81694
Sensitive: D – Preclinical
BCR-ABL1 E255K
CML
CUDC-907
Sensitive: D – Preclinical
BCR-ABL1 E255K
CML
dasatinib + imatinib
Resistant: D – Preclinical