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BIOMARKER:
BCR-ABL1 L248V
i
Other names:
BCR, BCR Activator Of RhoGEF And GTPase, BCR, RhoGEF And GTPase Activating Protein, Breakpoint Cluster Region Protein, Renal Carcinoma Antigen NY-REN-26, Breakpoint Cluster Region, D22S11, BCR1, BCR/FGFR1 Chimera Protein, FGFR1/BCR Chimera Protein, D22S662, ALL, CML, PHL, ABL proto-oncogene 1, ABL, c-ABL, JTK7, p150, ABL1
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Entrez ID:
25
;
613
Related biomarkers:
Expression
Mutation
CNA
Fusion
Others
‹
ABL1 T315I (5)
ABL1 E255K (2)
ABL1 G250E + ABL1 D276G + ABL1 T315I (2)
ABL1 D276G (1)
ABL1 F317L (1)
ABL1 F359V (1)
ABL1 G250E (1)
ABL1 L387M (1)
ABL1 M351T (1)
ABL1 T315I + ABL1 M351T + ABL1 L387M (1)
ABL1 Y253H (1)
BCR-ABL1 A337T (1)
BCR-ABL1 P465S (1)
BCR-ABL1 Q252H + BCR-ABL1 V299L (1)
BCR-ABL1 T315L (1)
BCR-ABL1 Y253H + BCR-ABL1 T315I (1)
ABL1 T315I (5)
ABL1 E255K (2)
ABL1 G250E + ABL1 D276G + ABL1 T315I (2)
ABL1 D276G (1)
ABL1 F317L (1)
ABL1 F359V (1)
ABL1 G250E (1)
ABL1 L387M (1)
ABL1 M351T (1)
ABL1 T315I + ABL1 M351T + ABL1 L387M (1)
ABL1 Y253H (1)
BCR-ABL1 A337T (1)
BCR-ABL1 P465S (1)
BCR-ABL1 Q252H + BCR-ABL1 V299L (1)
BCR-ABL1 T315L (1)
BCR-ABL1 Y253H + BCR-ABL1 T315I (1)
›
Associations
News
Trials
VERI cancer hierarchy
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BCR-ABL1 L248V
Chronic Myeloid Leukemia
BCR-ABL1 L248V
Chronic Myeloid Leukemia
dasatinib
Sensitive: B - Late Trials
dasatinib
Sensitive
:
B
dasatinib
Sensitive: B - Late Trials
dasatinib
Sensitive
:
B
BCR-ABL1 L248V
Chronic Myeloid Leukemia
BCR-ABL1 L248V
Chronic Myeloid Leukemia
imatinib
Resistant: C3 – Early Trials
imatinib
Resistant
:
C3
imatinib
Resistant: C3 – Early Trials
imatinib
Resistant
:
C3
BCR-ABL1 L248V
Chronic Myeloid Leukemia
BCR-ABL1 L248V
Chronic Myeloid Leukemia
bosutinib
Sensitive: C3 – Early Trials
bosutinib
Sensitive
:
C3
bosutinib
Sensitive: C3 – Early Trials
bosutinib
Sensitive
:
C3
BCR-ABL1 L248V
Chronic Myeloid Leukemia
BCR-ABL1 L248V
Chronic Myeloid Leukemia
dasatinib + imatinib + nilotinib
Resistant: D – Preclinical
dasatinib + imatinib + nilotinib
Resistant
:
D
dasatinib + imatinib + nilotinib
Resistant: D – Preclinical
dasatinib + imatinib + nilotinib
Resistant
:
D
BCR-ABL1 L248V
Chronic Myeloid Leukemia
BCR-ABL1 L248V
Chronic Myeloid Leukemia
nilotinib
Sensitive: D – Preclinical
nilotinib
Sensitive
:
D
nilotinib
Sensitive: D – Preclinical
nilotinib
Sensitive
:
D
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