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BIOMARKER:
BCL2 G101V
i
Other names:
BCL2, Bcl-2, PPP1R50, B-cell CLL/lymphoma 2
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Entrez ID:
596
Related biomarkers:
Expression
Mutation
CNA
Fusion
Others
‹
BCL2/BCL2L1 ratio elevation (3)
BCL2 rearrangement + MYC amplification (2)
BCL2/MCL1 ratio elevation (2)
BCL2 elevation + IGH elevation (1)
BCL2 fusion + EZH2 mutation (1)
Chr t(11;14) + BCL2 : BCL2L1 ratio elevation (1)
Chr t(11;14) + BCL2 overexpression (1)
MYC amplification + BCL2 amplification + TNFRSF8 expression (1)
PTEN deletion + BCL2 translocation (1)
BCL2/BAX ratio elevation (0)
BCL2/BCL2L1 ratio elevation (3)
BCL2 rearrangement + MYC amplification (2)
BCL2/MCL1 ratio elevation (2)
BCL2 elevation + IGH elevation (1)
BCL2 fusion + EZH2 mutation (1)
Chr t(11;14) + BCL2 : BCL2L1 ratio elevation (1)
Chr t(11;14) + BCL2 overexpression (1)
MYC amplification + BCL2 amplification + TNFRSF8 expression (1)
PTEN deletion + BCL2 translocation (1)
BCL2/BAX ratio elevation (0)
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Trials
VERI cancer hierarchy
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BCL2 G101V
Chronic Lymphocytic Leukemia
BCL2 G101V
Chronic Lymphocytic Leukemia
venetoclax + rituximab
Resistant: C3 – Early Trials
venetoclax + rituximab
Resistant
:
C3
venetoclax + rituximab
Resistant: C3 – Early Trials
venetoclax + rituximab
Resistant
:
C3
BCL2 G101V
Chronic Lymphocytic Leukemia
BCL2 G101V
Chronic Lymphocytic Leukemia
venetoclax + obinutuzumab
Resistant: C3 – Early Trials
venetoclax + obinutuzumab
Resistant
:
C3
venetoclax + obinutuzumab
Resistant: C3 – Early Trials
venetoclax + obinutuzumab
Resistant
:
C3
BCL2 G101V
Chronic Lymphocytic Leukemia
BCL2 G101V
Chronic Lymphocytic Leukemia
BGB-11417
Sensitive: D – Preclinical
BGB-11417
Sensitive
:
D
BGB-11417
Sensitive: D – Preclinical
BGB-11417
Sensitive
:
D
BCL2 G101V
Chronic Lymphocytic Leukemia
BCL2 G101V
Chronic Lymphocytic Leukemia
venetoclax
Resistant: D – Preclinical
venetoclax
Resistant
:
D
venetoclax
Resistant: D – Preclinical
venetoclax
Resistant
:
D
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