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BIOMARKER:
BCL2 fusion + EZH2 mutation
i
Other names:
BCL2, Bcl-2, PPP1R50, B-cell CLL/lymphoma 2, EZH2, ENX-1, EZH1, KMT6, KMT6A, Enhancer of zeste 2 polycomb repressive complex 2 subunit
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Entrez ID:
596
;
2146
Related biomarkers:
Expression
Mutation
CNA
Fusion
Others
‹
MYC rearrangement + BCL2 rearrangement (22)
EZH2 mutation (13)
BCL2 mutation (6)
MYC rearrangement + BCL2 rearrangement + BCL6 rearrangement (6)
EZH2 Y641F (5)
BCL2 G101V (4)
BCL2 rearrangement (3)
MYC translocation + BCL2 translocation (3)
BCL2 D103Y (2)
EZH2 W113C (2)
EZH2 Y641 (2)
BCL2 F104I (1)
BCL2 G101V + SF3B1 mutation (1)
BCL2 N103E (1)
BCL2 N103Y (1)
BCL2 N107_N110dup (1)
BCL2 V156N (1)
EZH2 mutation + BCL2 translocation (1)
MYC translocation + BCL6 translocation + BCL2 translocation (1)
TP53 mutation + BCL2 rearrangement (1)
BRAF V600E + TERT E441del + RET N579K + EZH2 D154E + CDK4 S259L (1)
EZH2 A490T (1)
EZH2 A682G (1)
EZH2 Y646 (1)
EZH2 Y646F (1)
EZH2 rs201135441C>T (1)
EZH2 rs2302427C>G (1)
BCL2 translocation (0)
MYC rearrangement + BCL2 rearrangement+ BCL6 rearrangement (0)
EZH2 wild-type (0)
MYC rearrangement + BCL2 rearrangement (22)
EZH2 mutation (13)
BCL2 mutation (6)
MYC rearrangement + BCL2 rearrangement + BCL6 rearrangement (6)
EZH2 Y641F (5)
BCL2 G101V (4)
BCL2 rearrangement (3)
MYC translocation + BCL2 translocation (3)
BCL2 D103Y (2)
EZH2 W113C (2)
EZH2 Y641 (2)
BCL2 F104I (1)
BCL2 G101V + SF3B1 mutation (1)
BCL2 N103E (1)
BCL2 N103Y (1)
BCL2 N107_N110dup (1)
BCL2 V156N (1)
EZH2 mutation + BCL2 translocation (1)
MYC translocation + BCL6 translocation + BCL2 translocation (1)
TP53 mutation + BCL2 rearrangement (1)
BRAF V600E + TERT E441del + RET N579K + EZH2 D154E + CDK4 S259L (1)
EZH2 A490T (1)
EZH2 A682G (1)
EZH2 Y646 (1)
EZH2 Y646F (1)
EZH2 rs201135441C>T (1)
EZH2 rs2302427C>G (1)
BCL2 translocation (0)
MYC rearrangement + BCL2 rearrangement+ BCL6 rearrangement (0)
EZH2 wild-type (0)
›
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VERI cancer hierarchy
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BCL2 fusion + EZH2 mutation
Diffuse Large B Cell Lymphoma
BCL2 fusion + EZH2 mutation
Diffuse Large B Cell Lymphoma
venetoclax + tazemetostat
Sensitive: D – Preclinical
venetoclax + tazemetostat
Sensitive
:
D
venetoclax + tazemetostat
Sensitive: D – Preclinical
venetoclax + tazemetostat
Sensitive
:
D
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