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DRUG:

AZD8055

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Company:

AstraZeneca

Drug class:

mTOR inhibitor

Related drugs:

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PTEN mutation	Prostate Cancer	PTEN mutation	Prostate Cancer	dasatinib + AZD8055 Sensitive: D – Preclinical dasatinib + AZD8055 Sensitive : D	dasatinib + AZD8055 Sensitive: D – Preclinical dasatinib + AZD8055 Sensitive : D
KRAS mutation	Colorectal Cancer	KRAS mutation	Colorectal Cancer	ABT 263 + AZD8055 Sensitive: D – Preclinical ABT 263 + AZD8055 Sensitive : D	ABT 263 + AZD8055 Sensitive: D – Preclinical ABT 263 + AZD8055 Sensitive : D
BRAF mutation	Colorectal Cancer	BRAF mutation	Colorectal Cancer	ABT 263 + AZD8055 Sensitive: D – Preclinical ABT 263 + AZD8055 Sensitive : D	ABT 263 + AZD8055 Sensitive: D – Preclinical ABT 263 + AZD8055 Sensitive : D
MTOR A2034V	Breast Cancer	MTOR A2034V	Breast Cancer	AZD8055 Sensitive: D – Preclinical AZD8055 Sensitive : D	AZD8055 Sensitive: D – Preclinical AZD8055 Sensitive : D
GNAQ Q209P	Uveal Melanoma	GNAQ Q209P	Uveal Melanoma	selumetinib + AZD8055 Sensitive: D – Preclinical selumetinib + AZD8055 Sensitive : D	selumetinib + AZD8055 Sensitive: D – Preclinical selumetinib + AZD8055 Sensitive : D
BRAF V600E	Uveal Melanoma	BRAF V600E	Uveal Melanoma	selumetinib + AZD8055 Sensitive: D – Preclinical selumetinib + AZD8055 Sensitive : D	selumetinib + AZD8055 Sensitive: D – Preclinical selumetinib + AZD8055 Sensitive : D
GNAQ Q209L	Uveal Melanoma	GNAQ Q209L	Uveal Melanoma	selumetinib + AZD8055 Sensitive: D – Preclinical selumetinib + AZD8055 Sensitive : D	selumetinib + AZD8055 Sensitive: D – Preclinical selumetinib + AZD8055 Sensitive : D
PIK3CA mutation	Squamous Cell Carcinoma of Head and Neck	PIK3CA mutation	Squamous Cell Carcinoma of Head and Neck	cetuximab + AZD8055 Sensitive: D – Preclinical cetuximab + AZD8055 Sensitive : D	cetuximab + AZD8055 Sensitive: D – Preclinical cetuximab + AZD8055 Sensitive : D
RICTOR amplification	Small Cell Lung Cancer	RICTOR amplification	Small Cell Lung Cancer	AZD8055 Sensitive: D – Preclinical AZD8055 Sensitive : D	AZD8055 Sensitive: D – Preclinical AZD8055 Sensitive : D
TP53 mutation	Hepatocellular Cancer	TP53 mutation	Hepatocellular Cancer	capivasertib + AZD8055 Sensitive: D – Preclinical capivasertib + AZD8055 Sensitive : D	capivasertib + AZD8055 Sensitive: D – Preclinical capivasertib + AZD8055 Sensitive : D