^
Association details:
Biomarker:RICTOR amplification
Cancer:Small Cell Lung Cancer
Drug:AZD8055 (mTOR inhibitor)
Direction:Sensitive
Evidence:
Evidence Level:
Sensitive: D – Preclinical
New
Source:
Title:

RICTOR amplification identifies a subgroup in small cell lung cancer and predicts response to drugs targeting mTOR

Excerpt:
In parallel, cells with RICTOR copy number (CN) gain showed increased sensitivity to three mTOR inhibitors, AZD8055, AZD2014 and INK128 in cell growth assays, with AZD2014 demonstrating the best inhibition of downstream signaling.
DOI:
10.18632/oncotarget.13362