^
Association details:
| Biomarker: | MTOR A2034V |
|---|---|
| Cancer: | Breast Cancer |
| Drug: | AZD8055 (mTOR inhibitor) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
Overcoming mTOR Resistance Mutations with a New Generation mTOR Inhibitor
Excerpt:
Mouse xenografts of MCF-7 cells expressing the RR1 mutant A2034V mTOR showed significantly less sensitivity to rapamycin yet maintained full sensitivity to AZD8055 and RapaLink-1 treatment.
