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DRUG CLASS:

Arginine depleter

DRUG CLASS:

Arginine depleter

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Related drugs:

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pegargiminase (3)

pegargiminase (3)

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ASS1 mutation	Malignant Pleural Mesothelioma	ASS1 mutation	Malignant Pleural Mesothelioma	cisplatin + pemetrexed + pegargiminase Sensitive: C3 – Early Trials cisplatin + pemetrexed + pegargiminase Sensitive : C3	cisplatin + pemetrexed + pegargiminase Sensitive: C3 – Early Trials cisplatin + pemetrexed + pegargiminase Sensitive : C3
ASS1 negative	Uveal Melanoma	ASS1 negative	Uveal Melanoma	cisplatin + pemetrexed + pegargiminase Sensitive: C3 – Early Trials cisplatin + pemetrexed + pegargiminase Sensitive : C3	cisplatin + pemetrexed + pegargiminase Sensitive: C3 – Early Trials cisplatin + pemetrexed + pegargiminase Sensitive : C3
ASS1 underexpression	Pancreatic Ductal Adenocarcinoma	ASS1 underexpression	Pancreatic Ductal Adenocarcinoma	panobinostat + pegargiminase Sensitive: D – Preclinical panobinostat + pegargiminase Sensitive : D	panobinostat + pegargiminase Sensitive: D – Preclinical panobinostat + pegargiminase Sensitive : D