^
Association details:
| Biomarker: | ASS1 underexpression |
|---|---|
| Cancer: | Pancreatic Ductal Adenocarcinoma |
| Drug: | Farydak (panobinostat) (HDAC inhibitor) + Hepacid (pegargiminase) (Arginine depleter) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
Abstract 554: Histone deacetylase inhibition is synthetically lethal with arginine deprivation in pancreatic cancers with low argininosuccinate synthetase 1 expression
Published date:
05/15/2020
Excerpt:
Compared to single agents, the combination of PAN and ADI-PEG20 showed better efficacy in suppressing ASS1-low PDAC tumor growth in mouse xenograft models.
DOI:
10.1158/1538-7445.AM2020-554
