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DRUG:

alisertib (MLN8237)

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Company:

Puma, Takeda

Drug class:

Aurora kinase A inhibitor

Related drugs:

HER-2 negative	HER2 Negative Breast Cancer	HER-2 negative	HER2 Negative Breast Cancer	MLN8237 Sensitive: C2 – Inclusion Criteria MLN8237 Sensitive : C2	MLN8237 Sensitive: C2 – Inclusion Criteria MLN8237 Sensitive : C2
KDM1A expression	Breast Cancer	KDM1A expression	Breast Cancer	MLN8237 Sensitive: C3 – Early Trials MLN8237 Sensitive : C3	MLN8237 Sensitive: C3 – Early Trials MLN8237 Sensitive : C3
ER positive	Estrogen Receptor Positive Breast Cancer	ER positive	Estrogen Receptor Positive Breast Cancer	MLN8237 Sensitive: C3 – Early Trials MLN8237 Sensitive : C3	MLN8237 Sensitive: C3 – Early Trials MLN8237 Sensitive : C3
TCF3-EPAS1 fusion	Acute Lymphocytic Leukemia	TCF3-EPAS1 fusion	Acute Lymphocytic Leukemia	MLN8237 Sensitive: D – Preclinical MLN8237 Sensitive : D	MLN8237 Sensitive: D – Preclinical MLN8237 Sensitive : D
AURKA overexpression	Esophageal Cancer	AURKA overexpression	Esophageal Cancer	MLN8237 Sensitive: D – Preclinical MLN8237 Sensitive : D	MLN8237 Sensitive: D – Preclinical MLN8237 Sensitive : D
MYC overexpression	Thyroid Gland Carcinoma	MYC overexpression	Thyroid Gland Carcinoma	MLN8237 Sensitive: D – Preclinical MLN8237 Sensitive : D	MLN8237 Sensitive: D – Preclinical MLN8237 Sensitive : D
CBFA2T3 - GLIS2 fusion	Acute Myelogenous Leukemia	CBFA2T3 - GLIS2 fusion	Acute Myelogenous Leukemia	MLN8237 Sensitive: D – Preclinical MLN8237 Sensitive : D	MLN8237 Sensitive: D – Preclinical MLN8237 Sensitive : D
RB1 deletion	Mesothelioma	RB1 deletion	Mesothelioma	MLN8237 Sensitive: D – Preclinical MLN8237 Sensitive : D	MLN8237 Sensitive: D – Preclinical MLN8237 Sensitive : D
HMGA2 overexpression	Prostate Cancer	HMGA2 overexpression	Prostate Cancer	MLN8237 Sensitive: D – Preclinical MLN8237 Sensitive : D	MLN8237 Sensitive: D – Preclinical MLN8237 Sensitive : D