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    Association details:
    Biomarker:RB1 deletion
    Cancer:Mesothelioma
    Drug:alisertib (MLN8237) (Aurora kinase A inhibitor)
    Direction:Sensitive
    Evidence:
    Evidence Level:
    Sensitive: D – Preclinical
    Source:
    Cancer Discov
    Title:

    Integrated genomics point to immune vulnerabilities in pleural mesothelioma

    Published date:
    09/27/2021
    Excerpt:
    We also found previously unrecognised deletions in RB1 in 26% of cases and show sub-micromolar responses to downstream PLK1, CHEK1 and Aurora Kinase inhibitors in primary mesothelioma cells.
    DOI:
    https://www.nature.com/articles/s41598-021-98414-w