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Association details:
| Biomarker: | CBFA2T3 - GLIS2 fusion |
|---|---|
| Cancer: | Acute Myelogenous Leukemia |
| Drug: | alisertib (MLN8237) (Aurora kinase A inhibitor) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
Characterization of novel genomic alterations and therapeutic approaches using acute megakaryoblastic leukemia xenograft models
Published date:
10/22/2012
Excerpt:
...in vivo treatment of mice xenografted with human AMKL cells bearing the CBFA2T3-GLIS2 fusion with MLN8237 significantly reduced disease burden and prolonged survival of recipient mice.
DOI:
10.1084/jem.20121343
