^
    1year
    No Consensus RCHOP everyone says clearly inferior @graham74GC from what i have heard Prefer DA R- EPOCH Others like good old RCODX M RIVAC Disease Misbehaves Even More Correct Answer is 🤓 High-grade B-cell lymphomas (HGBLs) with MYC and BCL2 and/or BCL6 rearrangements (@MorphologyAmigo)
    BCL2 (B-cell CLL/lymphoma 2) • BCL6 (B-cell CLL/lymphoma 6)
    |
    BCL6 rearrangement • BCL2 rearrangement
    |
    Rituxan (rituximab)
    over1year
    Paging haematologists @tobyeyre82 @graham74GC What classification system will be you using and how would you treat a high grade B-cell lymphoma with MYC and BCL6 rearrangements? (@DrMarkOng)
    BCL6 (B-cell CLL/lymphoma 6)
    |
    MYC rearrangement + BCL6 rearrangement • MYC rearrangement • BCL6 rearrangement
    almost2years
    Double Hit (DH) vs Expressor DLBCL (DE) DE = IHC MYC+(>40%), BCL2+(>50%) ABC>GCB Bad Rx = RCHOP DH = FISH MYC+BCL2 and/or BCL6 rearrangement GCB>ABC Very bad (esp MYC+IG partner) Rx = DA-EPOCH-R? DH gene sig = RNA 50% negative for MYC+BCL2 rearrangement Very bad Rx = ??? (@AaronGoodman33)
    MYC (V-myc avian myelocytomatosis viral oncogene homolog) • BCL2 (B-cell CLL/lymphoma 2) • BCL6 (B-cell CLL/lymphoma 6)
    |
    MYC rearrangement + BCL2 rearrangement • MYC rearrangement • BCL6 rearrangement • BCL2 rearrangement
    |
    Rituxan (rituximab)
    over2years
    Double Hit (DH) vs Expressor DLBCL (DE) DE = IHC MYC+(>40%), BCL2+(>50%) ABC>GCB Bad Rx = RCHOP DH = FISH MYC+BCL2 and/or BCL6 rearrangement GCB>ABC Very bad (esp MYC+IG) Rx = RCHOP or DA-EPOCH-R? DH gene sig = RNA 50% negative for MYC+BCL2 rearrangement Very bad Rx = ??? (@AaronGoodman33)
    MYC (V-myc avian myelocytomatosis viral oncogene homolog) • BCL2 (B-cell CLL/lymphoma 2) • BCL6 (B-cell CLL/lymphoma 6)
    |
    MYC rearrangement + BCL2 rearrangement • MYC rearrangement • BCL6 rearrangement • BCL2 rearrangement
    |
    Rituxan (rituximab)