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TOP2A IQFISH pharmDx is designed to detect amplifications and deletions (copy number changes) of the TOP2A gene using fluorescence in situ hybridization (FISH) technique on formalin-fixed, paraffin-embedded human breast cancer tissue specimens. It is indicated as an aid to predict recurrence-free and overall survival in high-risk breast cancer patients treated with adjuvant epirubicin-based chemotherapy.
Cancer:
Breast Cancer
Gene:
TOP2A (DNA topoisomerase 2-alpha)
Method:
Fluorescence in situ hybridization (FISH)
Approvals
Date
Cancer
Gene
Drug
By
01/11/08
FDA
Confirmatory trial(s)