Tempus xM is a liquid biopsy approach to MRD assessment, where no baseline tumor tissue is required. The assay delivers a binary MRD assessment based on both methylation and genomic variant MRD classifiers, while applying algorithms that support filtering of artifacts, clonal hematopoiesis of indeterminate potential (CHIP) and germline variants. It is designed to identify and surveil patients with low levels of circulating tumor DNA who are at risk of recurrence and may benefit from more intensive or novel therapy post-surgery.